Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | PLEC | Q15149 | 1/20 | 0.46 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.45 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.45 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.45 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13993348 | 0.94 | PDK1 (0.43) | MAPTGAAHTTLMNAL3MBTL1 | |
| SCHEMBL419955 | 0.94 | MAPT (0.52) | MAPTGAAHTTLMNAL3MBTL1 | |
| SCHEMBL10123376 | 0.84 | PDK1 (0.60) | MAPTGAAHTTLMNAL3MBTL1 | |
| SCHEMBL10123580 | 0.81 | HTT (0.50) | MAPTGAAHTTLMNAL3MBTL1 | |
| SCHEMBL10123473 | 0.80 | PDK1 (0.62) | MAPTGAAHTTLMNATP53 | |
| SCHEMBL420632 | 0.78 | MAPT (0.67) | MAPTGAAHTTLMNAL3MBTL1 | |
| SCHEMBL10123460 | 0.75 | PDK1 (0.49) | MAPTGAAHTTLMNAL3MBTL1 | |
| SCHEMBL10123374 | 0.75 | GAA (0.58) | MAPTGAAHTTLMNAL3MBTL1 | |
| SCHEMBL10123470 | 0.74 | MAPT (0.64) | MAPTGAAHTTLMNAL3MBTL1 | |
| SCHEMBL420196 | 0.74 | HTT (0.56) | MAPTGAAHTTLMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012060820-A1 | SULFONYL SEMICARBAZIDES, SEMICARBAZIDES AND UREAS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS FOR TREATING HEMORRHAGIC FEVER VIRUSES, INCLUDING INFECTIONS ASSOCIATED WITH ARENAVIRUSES | SIGA TECHNOLOGIES, INC. (US) | 2012-05-10 | — | — | WO | disclosed |