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PDK1

[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial · Q15118 · PDK1 on Sugi Atlas →

68,992 patent compounds predicted against PDK1, 36,475 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL355700 SCHEMBL355700 0.46 9/20
SCHEMBL331761 SCHEMBL331761 0.52 7/20
SCHEMBL291862 SCHEMBL291862 0.54 6/20
SCHEMBL305277 SCHEMBL305277 0.52 6/20
SCHEMBL305278 SCHEMBL305278 0.52 6/20
SCHEMBL306580 SCHEMBL306580 0.52 6/20
SCHEMBL6969 SCHEMBL6969 0.41 6/20
SCHEMBL291691 SCHEMBL291691 0.52 5/20
SCHEMBL304803 SCHEMBL304803 0.50 5/20
SCHEMBL304804 SCHEMBL304804 0.50 5/20
SCHEMBL104093 SCHEMBL104093 0.47 5/20
SCHEMBL13664 SCHEMBL13664 0.35 5/20
Bis(Piperidinylthiocarbonyl)Disulfide Bis(Piperidinylthiocarbonyl)Disulfide (SCHEMBL139465) 0.60 4/20
SCHEMBL380901 SCHEMBL380901 0.53 4/20
SCHEMBL83283 SCHEMBL83283 0.50 4/20
SCHEMBL202154 SCHEMBL202154 0.46 4/20
SCHEMBL60605 SCHEMBL60605 0.41 4/20
Norelgestromin Norelgestromin (SCHEMBL118611) 0.73 3/20
Norgestimate Norgestimate (SCHEMBL38317) 0.55 3/20
Norgestimate Norgestimate (SCHEMBL38318) 0.55 3/20

Clinical trials — most relevant to PDK1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Prevention of Renal Complications of Diabetes With Thiamine PHASE4UNKNOWN
Topical Metformin Emulgel VS Salicylic Acid Peeling in Treatment of Acne Vulgaris PHASE4UNKNOWN
Glutamate for Metabolic Intervention in Coronary Surgery PHASE3COMPLETED
Acetylcarnitine and Insulin Sensitivity PHASE2COMPLETED
Thiamine as an Adjunctive Therapy in Cardiac Surgery PHASE2COMPLETED
Efficacy and Safety of the Treatment of Pyruvate Dehydrogenase Deficiency Patients With Glycerol Phenylbutyrate (RAVICTI) PHASE2RECRUITING
Thiamine as Adjunctive Therapy for Diabetic Ketoacidosis PHASE2COMPLETED
Metformin Plus/Minus Fasting Mimicking Diet to Target the Metabolic Vulnerabilities of LKB1-inactive Lung Adenocarcinoma PHASE2UNKNOWN
Magnetic Resonance Imaging (MRI) With Hyperpolarized Pyruvate (13C) as Diagnostic Tool in Advanced Prostate Cancer PHASE2SUSPENDED
Simultaneous Hyperpolarized [1-13C]Pyruvate and 18F-FDG PET/MRS in Cancer Patients PHASE2UNKNOWN
To Assess Safety of Mitapivat and Provide Proof of Concept of the Efficacy of the Drug in Patients With RBC Membranopathies or CDAII. PHASE2RECRUITING
Prevention of Acute Myocardial Injury by Trimetazidine in Patients Hospitalized for COVID-19 PHASE2UNKNOWN
Dichloroacetate (DCA) for the Treatment of Pulmonary Arterial Hypertension PHASE1COMPLETED
Safety, Tolerability and Pharmacokinetics of Benfo-Oxythiamine (B-OT) in Healthy Volunteers PHASE1COMPLETED
A Phase I, Open-Labeled, Single-Arm, Dose Escalation, Clinical and Pharmacology Study of Dichloroacetate (DCA) in Patients With Recurrent and/or Metastatic Solid Tumours PHASE1COMPLETED
Imaging of Traumatic Brain Injury Metabolism Using Hyperpolarized Carbon-13 Pyruvate EARLY_PHASE1ENROLLING_BY_INVITATION
UTSW HP [13-C] Pyruvate Injection in HCM nanCOMPLETED
Biologic Mechanisms for Pain Variation After Physical Activity in Osteoarthritis nanCOMPLETED
Alternative Substrates in the Critically Ill Subject nanCOMPLETED
Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation nanCOMPLETED
Natural History and Advanced Genetic Study of Pyruvate Dehydrogenase Complex Deficiencies nanRECRUITING
Natural History Study of Pyruvate Dehydrogenase Deficiency nanUNKNOWN
Regulation of Lymphocyte Anti-tumor Response in Metastatic Patients Treated With the mTOR Inhibitor Everolimus nanCOMPLETED
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes nanCOMPLETED
McArdle Disease Treatment by Ketogenic Diet nanCOMPLETED
Metabolic Remodeling in Pulmonary Arterial Hypertension (PAH) nanCOMPLETED
Thiamine As An Adjuvant Therapy For Hyperlactatemia In Septic Shock Patients nanUNKNOWN
Study of the Metabolism of Pyruvate and Related Problems in Patients With Lactic Acidemia nanCOMPLETED
13C Pyruvate DNP MR Spectroscopy for Lymphoma Treatment Response Assessment nanUNKNOWN
Role and Expression of MXRA5 in Placental Connective Tissue Remodelling in Preeclampsia nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a PDK1 binder may also engage these)

ProteinNameSimilarity
Q63065 — 1.000 Q63065 →
Q8BFP9 — 0.999 Q8BFP9 →
PDK3 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial 0.999 landscape →
Q1KMR4 — 0.999 Q1KMR4 →
Q64536 — 0.998 Q64536 →
O70571 — 0.998 O70571 →
O55028 — 0.996 O55028 →
BCKDK Branched-chain alpha-ketoacid dehydrogenase kinase 0.996 landscape →
Q02332 — 0.996 Q02332 →
Q9JK42 — 0.995 Q9JK42 →
O88345 — 0.995 O88345 →
Q00972 — 0.995 Q00972 →
O54937 — 0.994 O54937 →
Q922H2 — 0.993 Q922H2 →
O02623 — 0.993 O02623 →
Q2KJG8 — 0.993 Q2KJG8 →
PDK2 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 0.991 landscape →
P91622 — 0.991 P91622 →
PDK4 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 0.989 landscape →
Q9P6P9 — 0.989 Q9P6P9 →
Q9UUI7 — 0.986 Q9UUI7 →
B4NBB0 — 0.986 B4NBB0 →
Q8WYJ6 — 0.985 Q8WYJ6 →
Q9CQN1 — 0.985 Q9CQN1 →
F4IDQ6 — 0.985 F4IDQ6 →
P78875 — 0.985 P78875 →
P40530 — 0.985 P40530 →
Q5XI69 — 0.985 Q5XI69 →
B0XDC4 — 0.985 B0XDC4 →
TRAP1 Heat shock protein 75 kDa, mitochondrial 0.985 landscape →