Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NEK1 | Q96PY6 | 5/20 | 0.77 |
| ▸ | IKBKB | O14920 | 5/20 | 0.59 |
| ▸ | CHUK | O15111 | 5/20 | 0.59 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.50 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.50 |
| ▸ | JAK2 | O60674 | 2/20 | 0.50 |
| ▸ | PAK4 | O96013 | 2/20 | 0.50 |
| ▸ | CSF1R | P07333 | 2/20 | 0.50 |
| ▸ | RET | P07949 | 2/20 | 0.50 |
| ▸ | LTK | P29376 | 2/20 | 0.50 |
| ▸ | KDR | P35968 | 2/20 | 0.50 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.50 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.50 |
| ▸ | CLK2 | P49760 | 2/20 | 0.50 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.50 |
| ▸ | JAK3 | P52333 | 2/20 | 0.50 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.50 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.50 |
| ▸ | MST1R | Q04912 | 2/20 | 0.50 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10124944 | 0.88 | NEK1 (0.72) | NEK1IKBKBCHUKROCK1DAPK3 | |
| SCHEMBL10125151 | 0.88 | PRKCI (0.61) | NEK1IKBKBCHUKROCK1DAPK3 | |
| SCHEMBL10125090 | 0.85 | NEK1 (0.82) | NEK1IKBKBCHUKROCK1DAPK3 | |
| SCHEMBL14494460 | 0.84 | NEK1 (0.54) | NEK1IKBKBCHUKROCK1DAPK3 | |
| SCHEMBL4793711 | 0.82 | NEK1 (0.77) | NEK1IKBKBCHUKROCK1DAPK3 | |
| SCHEMBL4871172 | 0.82 | NEK1 (0.77) | NEK1IKBKBCHUKMAPK8CIT | |
| SCHEMBL4790856 | 0.81 | NEK1 (0.72) | NEK1IKBKBCHUKCIT | |
| SCHEMBL12346406 | 0.81 | NUDT1 (0.60) | NEK1IKBKBCHUKROCK1DAPK3 | |
| SCHEMBL858398 | 0.79 | NEK1 (0.72) | NEK1IKBKBCHUKCIT | |
| SCHEMBL4793417 | 0.79 | NEK1 (0.68) | NEK1IKBKBCHUKROCK1DAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8921376-B2 | Pyrrolopyridines useful as inhibitors of protein kinase | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-12-30 | — | — | US | disclosed |
| US-8921376-B2 | Pyrrolopyridines useful as inhibitors of protein kinase | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-12-30 | — | — | US | disclosed |
| EP-1881983-B1 | PYRROLOPYRIDINES USEFUL AS INHIBITORS OF PROTEIN KINASE | VERTEX PHARMA (US) | 2012-01-11 | — | — | EP | disclosed |
| US-20070135466-A1 | Pyrrolopyridines useful as inhibitors of protein kinase | VERTEX PHARMACEUTICALS INCORPORATED | 2007-06-14 | — | — | US | disclosed |
| US-20070135466-A1 | Pyrrolopyridines useful as inhibitors of protein kinase | VERTEX PHARMACEUTICALS INCORPORATED | 2007-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070135466-A1 | Pyrrolopyridines useful as inhibitors of protein kinase | JAK2, JAK1, JAK3 | NEK1 668/4885IKBKB 779/4885CHUK 297/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.