Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 8/20 | 0.62 |
| ▸ | IKBKB | O14920 | 2/20 | 0.46 |
| ▸ | CHUK | O15111 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.45 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | PAK4 | O96013 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | IGF1R | P08069 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4791074 | 0.87 | AKT1 (0.58) | AKT1IKBKBCHUKNUDT1NEK1 | |
| SCHEMBL12346430 | 0.86 | AKT1 (0.61) | AKT1IKBKBCHUKNUDT1NEK1 | |
| SCHEMBL8239427 | 0.85 | AKT1 (0.62) | AKT1IKBKBCHUKKDM4ENUDT1 | |
| SCHEMBL10125362 | 0.84 | AKT1 (0.59) | AKT1IKBKBCHUKKDM4ENPC1 | |
| SCHEMBL30649183 | 0.84 | AKT1 (0.61) | AKT1IKBKBCHUKNUDT1NEK1 | |
| SCHEMBL10125059 | 0.84 | AKT1 (0.61) | AKT1IKBKBCHUKNUDT1NEK1 | |
| SCHEMBL14493849 | 0.83 | AKT1 (0.67) | AKT1HPGDSCIT | |
| SCHEMBL4592540 | 0.83 | AKT1 (0.67) | AKT1IKBKBCHUKNUDT1NEK1 | |
| SCHEMBL14493840 | 0.83 | NEK1 (0.64) | AKT1IKBKBCHUKNUDT1NEK1 | |
| SCHEMBL14493838 | 0.83 | AKT1 (0.66) | AKT1IKBKBCHUKHPGDSCIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1881983-B1 | PYRROLOPYRIDINES USEFUL AS INHIBITORS OF PROTEIN KINASE | VERTEX PHARMA (US) | 2012-01-11 | — | — | EP | disclosed |