Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 15/20 | 0.67 |
| ▸ | AKT3 | Q9Y243 | 3/20 | 0.55 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.52 |
| ▸ | IKBKB | O14920 | 2/20 | 0.47 |
| ▸ | CHUK | O15111 | 2/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | AKT2 | P31751 | 3/20 | 0.45 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14493840 | 0.91 | NEK1 (0.64) | AKT1AKT3NEK1IKBKBCHUK | |
| SCHEMBL10125362 | 0.90 | AKT1 (0.59) | AKT1AKT3NEK1IKBKBCHUK | |
| SCHEMBL10124877 | 0.88 | AKT1 (0.57) | AKT1AKT3NEK1IKBKBCHUK | |
| SCHEMBL12346430 | 0.87 | AKT1 (0.61) | AKT1AKT3NEK1IKBKBCHUK | |
| SCHEMBL12346484 | 0.87 | AKT1 (0.56) | AKT1AKT3NEK1IKBKBCHUK | |
| SCHEMBL14494287 | 0.84 | AKT1 (0.58) | AKT1AKT3NEK1IKBKBCHUK | |
| SCHEMBL10124969 | 0.83 | AKT1 (0.62) | AKT1NEK1IKBKBCHUKROCK1 | |
| SCHEMBL30649183 | 0.83 | AKT1 (0.61) | AKT1NEK1IKBKBCHUKROCK1 | |
| SCHEMBL10125059 | 0.83 | AKT1 (0.61) | AKT1NEK1IKBKBCHUKROCK1 | |
| SCHEMBL14493849 | 0.82 | AKT1 (0.67) | AKT1AKT3AKT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |