Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.37 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.37 |
| ▸ | DTYMK | P23919 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | JAK1 | P23458 | 2/20 | 0.34 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.34 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.34 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15033820 | 0.83 | POLB (0.40) | POLBSQORGPR119DTYMKGRM5 | |
| SCHEMBL10125262 | 0.82 | POLB (0.39) | POLBSQORGPR119DTYMKGRM5 | |
| SCHEMBL10125419 | 0.79 | POLB (0.43) | POLBGPR119DTYMKGRM5JAK2 | |
| SCHEMBL2899250 | 0.79 | GRM5 (0.43) | POLBSQORGPR119DTYMKGRM5 | |
| SCHEMBL10125364 | 0.77 | GPR119 (0.42) | POLBGPR119DTYMKGRM5JAK2 | |
| SCHEMBL15033814 | 0.75 | GRM5 (0.40) | POLBGPR119DTYMKGRM5JAK2 | |
| SCHEMBL3886709 | 0.73 | GPR119 (0.46) | POLBGPR119DTYMKGRM5JAK2 | |
| SCHEMBL27449849 | 0.72 | AAK1 (0.45) | AAK1 | |
| SCHEMBL3555626 | 0.70 | POLB (0.48) | POLBSQORGPR119DTYMKGRM5 | |
| SCHEMBL31417101 | 0.70 | GPR119 (0.40) | POLBGPR119GRM5JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012022408-A1 | PYRIMIDINE DERIVATIVES AS FAK INHIBITORS | MERCK PATENT GMBH (DE) | 2012-02-23 | — | — | WO | disclosed |