Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2B | Q14289 | 10/20 | 0.51 |
| ▸ | KIF11 | P52732 | 4/20 | 0.49 |
| ▸ | PTK2 | Q05397 | 12/20 | 0.48 |
| ▸ | ULK1 | O75385 | 2/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.44 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.44 |
| ▸ | PLK1 | P53350 | 1/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | STK16 | O75716 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | PAK4 | O96013 | 1/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | PRKCG | P05129 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10125760 | 0.97 | PTK2B (0.51) | PTK2BKIF11PTK2ULK1GABRA1 | |
| SCHEMBL15023744 | 0.89 | PTK2B (0.49) | PTK2BKIF11PTK2ULK1GABRA1 | |
| SCHEMBL669843 | 0.88 | PTK2B (0.49) | PTK2BKIF11PTK2ULK1GABRA1 | |
| SCHEMBL10125381 | 0.86 | PTK2B (0.47) | PTK2BKIF11PTK2ULK1GABRA1 | |
| SCHEMBL15023735 | 0.83 | PTK2B (0.46) | PTK2BKIF11PTK2ULK1GABRA1 | |
| SCHEMBL669800 | 0.83 | PTK2B (0.46) | PTK2BKIF11PTK2ULK1GABRA1 | |
| SCHEMBL10125445 | 0.78 | PTK2 (0.46) | PTK2BPTK2GABRA1TMEM97PLK1 | |
| SCHEMBL668635 | 0.76 | PTK2 (0.46) | PTK2BPTK2GABRA1TMEM97PLK1 | |
| SCHEMBL670533 | 0.76 | PTK2 (0.53) | PTK2BPTK2PLK4AURKAPDPK1 | |
| SCHEMBL10125447 | 0.74 | PTK2 (0.58) | PTK2BPTK2PLK4AURKAPDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012022408-A1 | PYRIMIDINE DERIVATIVES AS FAK INHIBITORS | MERCK PATENT GMBH (DE) | 2012-02-23 | — | — | WO | disclosed |