PTK2B

Protein-tyrosine kinase 2-beta · Q14289 · PTK2B on Sugi Atlas →

59,923 patent compounds predicted against PTK2B, 45,072 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL21346 SCHEMBL21346 0.47 6/20
SCHEMBL20041 SCHEMBL20041 0.44 6/20
SCHEMBL19831 SCHEMBL19831 0.38 6/20
SCHEMBL147422 SCHEMBL147422 0.66 5/20
SCHEMBL108541 SCHEMBL108541 0.44 5/20
SCHEMBL146734 SCHEMBL146734 0.67 4/20
SCHEMBL144651 SCHEMBL144651 0.67 4/20
SCHEMBL146677 SCHEMBL146677 0.67 4/20
SCHEMBL144378 SCHEMBL144378 0.66 4/20
SCHEMBL142020 SCHEMBL142020 0.65 4/20
SCHEMBL147132 SCHEMBL147132 0.64 4/20
SCHEMBL142951 SCHEMBL142951 0.62 4/20
SCHEMBL147730 SCHEMBL147730 0.61 4/20
SCHEMBL147715 SCHEMBL147715 0.61 4/20
SCHEMBL143818 SCHEMBL143818 0.61 4/20
SCHEMBL144979 SCHEMBL144979 0.56 4/20
SCHEMBL19806 SCHEMBL19806 0.36 4/20
SCHEMBL93711 SCHEMBL93711 1.00 3/20
SCHEMBL93713 SCHEMBL93713 1.00 3/20
SCHEMBL147331 SCHEMBL147331 0.91 3/20

Clinical trials — most relevant to PTK2B by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
The Efficacy and Safety of Deucravacitinib in Takayasu's Arteritis PHASE4NOT_YET_RECRUITING
The Effect of the Preoperative Oral Carbohydrate Attenuating Immediate Postoperative Insulin Resistance on PI3K Dependent Signaling Pathway PHASE4COMPLETED
The G Protein-Coupled Receptor Kinase Type 2 Inhibitor Paroxetine as Adjunctive Therapy to Improve Insulin Sensitivity in Patients With Type 2 Diabetes Mellitus PHASE3UNKNOWN
Platelet Rich Plasma in Treatment of Melasma PHASE3UNKNOWN
ASLAN001 in Patients With Advanced or Metastatic Cholangiocarcinoma Who Progressed on at Least 1 Line of Systemic Therapy PHASE2COMPLETED
Neoadjuvant GW572016 to Treat Breast Cancer PHASE2COMPLETED
Phase II Study of Vandetanib in Individuals With Kidney Cancer PHASE2COMPLETED
Imatinib in Dermatofibrosarcoma Protuberans (DFSP) PHASE1/PHASE2COMPLETED
Selective Treatment According to Molecular Subtype of Prostate Cancer PHASE2UNKNOWN
Protein Tyrosine Kinases (PTK) in Multiple Myeloma PHASE2COMPLETED
Neoadjuvant Combination Therapy of Lenvatinib and TACE for Transplant-Eligible Large Hepatocellular Carcinoma Patients PHASE2ENROLLING_BY_INVITATION
PTK 787 and Gleevec in Patients With AML, AMM, and CML-BP PHASE1/PHASE2COMPLETED
Sunitinib Malate in Treating Younger Patients With Recurrent, Refractory, or Progressive Malignant Glioma or Ependymoma PHASE2COMPLETED
Sorafenib Combined With Erlotinib, Tipifarnib, or Temsirolimus in Treating Patients With Recurrent Glioblastoma Multiforme or Gliosarcoma PHASE1/PHASE2COMPLETED
Safety and Tolerability Study of TAK-165 in Subjects With Tumors Expressing HER2 PHASE1COMPLETED
A Dose Escalation Study of SF1126, a PI3 Kinase (PI3K) Inhibitor, Given By Intravenous (IV) Infusion in Patients With Solid Tumors PHASE1COMPLETED
FAK Inhibitor in Patients With Advanced Solid Tumors PHASE1NOT_YET_RECRUITING
Ad/HER2/Neu Dendritic Cell Cancer Vaccine Testing PHASE1COMPLETED
Safety and Efficacy of the Fully Humanized Anti - VEGF Monoclonal Antibody LYN00101 PHASE1WITHDRAWN
Radiation Therapy and Bortezomib and Cetuximab With or Without Cisplatin to Treat Head and Neck Cancer PHASE1COMPLETED
Effect of AIV007 by Periocular Administration in Subjects with Macular Edema Secondary to Neovascular Age-related Macular Degeneration (nAMD) and Diabetic Macular Edema (DME) PHASE1ACTIVE_NOT_RECRUITING
Effect of Intravitreally Administered AIV007 in Subjects With Neovascular Age-Related Macular Degeneration PHASE1COMPLETED
The Clinical Application of 68Ga Labeled ssDNA Aptamer Sgc8 in Healthy Volunteers and Colorectal Patients EARLY_PHASE1UNKNOWN
Clinical Study on the Application of 18F-HER2 Affibody PET Imaging in HER2-Expressing Breast Cancer nanRECRUITING
Pathological and Nuclear Medicine Factors for Prognosis in Lung Carcinoma nanCOMPLETED
Avapritinib in the Treatment of Unresectable or Recurrent Metastatic GIST Non-exon18 Mutations of PDGFRA nanRECRUITING
NTRK 1,2,3 Rearrangements in Patients With Solid Tumors nanACTIVE_NOT_RECRUITING
p-AKT Expression on Clinical Outcomes in Malignant Lymphoma nanCOMPLETED
K-RAS Oncogene Mutation in Patients With Advanced Non-Small Cell Lung Cancer Associated With Exposure to Wood Smoke and Tobacco Smoking: Therapeutic Implications nanCOMPLETED
Pertuzumab in First Line Treatment of HER2-positive Metastatic Breast Cancer Patients nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a PTK2B binder may also engage these)

ProteinNameSimilarity
P70600 1.000 P70600 →
Q9QVP9 1.000 Q9QVP9 →
PTK2 Focal adhesion kinase 1 0.996 landscape →
O35346 0.995 O35346 →
Q8BX57 0.995 Q8BX57 →
P34152 0.994 P34152 →
Q60629 0.993 Q60629 →
P25799 0.993 P25799 →
O12990 0.993 O12990 →
Q8N9S9 0.993 Q8N9S9 →
Q86YR7 0.992 Q86YR7 →
O15068 0.992 O15068 →
NFKB1 Nuclear factor NF-kappa-B p105 subunit 0.992 landscape →
Q63406 0.992 Q63406 →
F8VPU2 0.992 F8VPU2 →
Q9Y4G8 0.992 Q9Y4G8 →
Q00944 0.992 Q00944 →
INPP5B Type II inositol 1,4,5-trisphosphate 5-phosphatase 0.992 landscape →
Q64096 0.992 Q64096 →
Q95YD4 0.992 Q95YD4 →
Q9VZI3 0.992 Q9VZI3 →
P10911 0.992 P10911 →
Q9H1H9 0.992 Q9H1H9 →
O94887 0.991 O94887 →
F1M386 0.991 F1M386 →
Q60695 0.991 Q60695 →
O43150 0.991 O43150 →
Q2HJE1 0.991 Q2HJE1 →
F1PBJ0 0.991 F1PBJ0 →
P10686 0.991 P10686 →