Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.51 |
| ▸ | SLC17A5 | Q9NRA2 | 1/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.49 |
| ▸ | CASP3 | P42574 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MDM4 | O15151 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.44 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29400330 | 0.85 | MDM4 (0.52) | EPHX2PTPN1CASP3KMT2AMDM4 | |
| SCHEMBL7984402 | 0.85 | MDM4 (0.52) | EPHX2PTPN1CASP3KMT2AMDM4 | |
| SCHEMBL21838224 | 0.85 | MDM4 (0.52) | EPHX2PTPN1CASP3KMT2AMDM4 | |
| SCHEMBL12563729 | 0.85 | MDM4 (0.52) | EPHX2PTPN1CASP3KMT2AMDM4 | |
| SCHEMBL30057042 | 0.85 | MDM4 (0.52) | EPHX2PTPN1CASP3KMT2AMDM4 | |
| SCHEMBL10126071 | 0.84 | PTPN1 (0.45) | EPHX2SLC17A5PTPN1CASP3KMT2A | |
| SCHEMBL13767439 | 0.84 | KMT2A (0.49) | EPHX2SLC17A5KMT2ATP53 | |
| SCHEMBL28312907 | 0.83 | MDM4 (0.47) | EPHX2CASP3KMT2AMDM4TP53 | |
| SCHEMBL13132526 | 0.82 | TP53 (0.44) | EPHX2SLC17A5PTPN1CASP3KMT2A | |
| SCHEMBL702055 | 0.82 | LCK (0.55) | EPHX2PTPN1CASP3KMT2AMDM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8124368-B2 | Fluorogenic protein kinase substrates | Life Technologies Corporation (US) | 2012-02-28 | — | — | US | disclosed |
| WO-2008016762-A1 | FLUOROGENIC PROTEIN KINASE SUBSTRATES | INVITROGEN CORPORATION (US) | 2008-02-07 | — | — | WO | disclosed |
| US-20080009026-A1 | FLUOROGENIC PROTEIN KINASE SUBSTRATES | INVITROGEN CORPORATION (US) | 2008-01-10 | — | — | US | disclosed |