SCHEMBL10127460

SCHEMBL10127460

c1ccc2cc(-c3ccc4c(c3)c3ccccc3c3nnc(-c5ccc(-c6cccc7c6sc6ccccc67)cc5)n43)ccc2c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 1/20 0.41
MAPK9 P45984 1/20 0.39
MAPK14 Q16539 1/20 0.39
POLB P06746 1/20 0.38
PRKDC P78527 4/20 0.33
S1PR4 O95977 4/20 0.32
S1PR5 Q9H228 4/20 0.32
PARP14 Q460N5 1/20 0.32
AKT1 P31749 1/20 0.32
PDE10A Q9Y233 4/20 0.32
TUBB4A P04350 1/20 0.31
TUBB P07437 1/20 0.31
TUBA3C P0DPH7 1/20 0.31
TUBA1B P68363 1/20 0.31
TUBA4A P68366 1/20 0.31
TUBB4B P68371 1/20 0.31
TUBB3 Q13509 1/20 0.31
TUBB2A Q13885 1/20 0.31
TUBB8 Q3ZCM7 1/20 0.31
TUBA3E Q6PEY2 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10127483 0.99 ALOX5 (0.40) ALOX5MAPK9MAPK14POLBPRKDC
SCHEMBL10128379 0.97 ALOX5 (0.40) ALOX5MAPK9MAPK14POLBPRKDC
SCHEMBL10127477 0.92 ALOX5 (0.41) ALOX5MAPK9MAPK14POLBPRKDC
SCHEMBL10127457 0.91 ALOX5 (0.44) ALOX5MAPK9MAPK14POLBPRKDC
SCHEMBL10127448 0.91 ALOX5 (0.43) ALOX5MAPK9MAPK14POLBPRKDC
SCHEMBL10128378 0.91 ALOX5 (0.43) ALOX5MAPK9MAPK14POLBPRKDC
SCHEMBL10127470 0.91 ALOX5 (0.43) ALOX5MAPK9MAPK14POLBPRKDC
SCHEMBL515975 0.91 ALOX5 (0.43) ALOX5MAPK9MAPK14POLBPRKDC
SCHEMBL10128406 0.91 ALOX5 (0.43) ALOX5MAPK9MAPK14POLBPRKDC
SCHEMBL10127472 0.90 ALOX5 (0.42) ALOX5MAPK9MAPK14POLBPRKDC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9034486-B2 Triazole derivative, heterocyclic compound, light-emitting element, light-emitting device, electronic device and lighting device SEMICONDUCTOR ENERGY LABORATORY CO., LTD (JP) 2015-05-19 US disclosed
US-9034486-B2 Triazole derivative, heterocyclic compound, light-emitting element, light-emitting device, electronic device and lighting device SEMICONDUCTOR ENERGY LABORATORY CO., LTD (JP) 2015-05-19 US disclosed
WO-2012017842-A1 TRIAZOLE DERIVATIVE, HETEROCYCLIC COMPOUND, LIGHT-EMITTING ELEMENT, LIGHT-EMITTING DEVICE, ELECTRONIC DEVICE AND LIGHTING DEVICE SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2012-02-09 WO disclosed
US-20120025697-A1 Triazole Derivative, Heterocyclic Compound, Light-Emitting Element, Light-Emitting Device, Electronic Device and Lighting Device SEMICONDUCTOR ENERGY LABORATORY CO., LTD. 2012-02-02 US disclosed
US-20120025697-A1 Triazole Derivative, Heterocyclic Compound, Light-Emitting Element, Light-Emitting Device, Electronic Device and Lighting Device SEMICONDUCTOR ENERGY LABORATORY CO., LTD. 2012-02-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120025697-A1 Triazole Derivative, Heterocyclic Compound, Light-Emitting Element, Light-Emitting Device, Electronic Device and Lighting Device HTR3D, KCNQ4, KCNQ3 ALOX5 1457/4885MAPK9 2678/4885MAPK14 1202/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.