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Sugi Predict / Targets / ALOX5

ALOX5

Polyunsaturated fatty acid 5-lipoxygenase · P09917 · ALOX5 on Sugi Atlas →

446,168 patent compounds predicted against ALOX5, 213,348 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
Idebenone Idebenone (SCHEMBL28320) 0.55 12/20
SCHEMBL24086 SCHEMBL24086 0.65 10/20
SCHEMBL36399 SCHEMBL36399 0.44 10/20
Phenoxazine Phenoxazine (SCHEMBL7862) 1.00 9/20
SCHEMBL24077 SCHEMBL24077 0.65 9/20
Ubidecarenone Ubidecarenone (SCHEMBL19858) 0.62 9/20
SCHEMBL5161 SCHEMBL5161 0.59 9/20
SCHEMBL25006 SCHEMBL25006 0.59 9/20
Lonazolac Lonazolac (SCHEMBL25221) 0.86 8/20
SCHEMBL49737 SCHEMBL49737 0.50 8/20
SCHEMBL49620 SCHEMBL49620 0.46 7/20
Zileuton Zileuton (SCHEMBL4209) 1.00 6/20
Pterostilbene Pterostilbene (SCHEMBL20063) 1.00 6/20
SCHEMBL38839 SCHEMBL38839 0.54 6/20
SCHEMBL39849 SCHEMBL39849 0.54 6/20
SCHEMBL59744 SCHEMBL59744 0.54 6/20
SCHEMBL39347 SCHEMBL39347 0.50 6/20
SCHEMBL46289 SCHEMBL46289 0.45 6/20
SCHEMBL46736 SCHEMBL46736 0.45 6/20
Tebufelone Tebufelone (SCHEMBL43674) 1.00 5/20

Clinical trials — most relevant to ALOX5 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Predicting Response to Standardized Pediatric Colitis Therapy PHASE4COMPLETED
The Effect of Ticagrelor on 15-Epi-Lipoxin A4 and Inflammation PHASE4WITHDRAWN
Diet Rich in N-3 Polyunsaturated Fatty Acids in Renal Transplant Recipients PHASE4COMPLETED
The Effects of Eicosapentaenoic Acid (EPA), Gamma-Linolenic Acid (GLA) and Antioxidants in the Treatment of Sepsis PHASE4COMPLETED
Obesity and Asthma: Nutrigenetic Response to Omega-3 Fatty Acids PHASE2/PHASE3COMPLETED
Chemoprevention Trial in Familial Adenomatous Polyposis (FAP) Coli Using EPA PHASE2/PHASE3COMPLETED
Aspirin for Uncontrolled Asthma PHASE3COMPLETED
Montelukast in Parkinson Disease PHASE2/PHASE3RECRUITING
GSK2190915 Neutrophilic Asthma Study PHASE2COMPLETED
Phase II A Trial of Curcumin Among Patients With Prevalent Subclinical Neoplastic Lesions (Aberrant Crypt Foci) PHASE2COMPLETED
Zileuton With or Without Celecoxib As Chemopreventive Agents in Smokers PHASE1/PHASE2COMPLETED
Acute Pseudophakic Cystoid Macular Edema Treatment Trial: Intravitreal Ranibizumab Versus Triamcinolone Acetonide PHASE1COMPLETED
GSK2190915A - Bioavailability Study PHASE1COMPLETED
A Repeat Dose Study to Investigate the Interaction of GSK2190915 on the Pharmacokinetics of Rosuvastatin PHASE1COMPLETED
A Single Dose Study to Assess the Regional Absorption and Bioavailability of 100mg GSK2190915A PHASE1COMPLETED
Trial of Zileuton CR in Children and Adults With Sickle Cell Disease PHASE1COMPLETED
Role of 12-lipoxygenase in Platelet Reactivity and Type 2 Diabetes Mellitus EARLY_PHASE1COMPLETED
Heart & Health Study nanCOMPLETED
Fish Oil to Prevent Asthma Exacerbations in Patients With ALOX5 Polymorphisms nanCOMPLETED
Fatty Acid Regulation of Platelet Function in Diabetes nanCOMPLETED
Lipidomics Screening of Anti-inflammatory Drugs and Drug Candidates in Vitro - Part A nanACTIVE_NOT_RECRUITING
Lipidomics Screening of Celecoxib in ex Vivo Human Whole Blood Assay - Part B nanCOMPLETED
Study of the Arachidonate 5-Lipoxygenase Enzyme in Affecting the Risk for Coronary Heart Disease nanCOMPLETED
EPICO: (Study for the Pro-resolution of Chronic Inflammation in Obesity. Original Acronym From Spanish) nanUNKNOWN
PLatelets Acetyl-CoA Carboxylase Phosphorylation State in SEPtic Shock nanCOMPLETED
Oxidative Lipidomic Biomarkers During Mechanical Ventilation in Critically Ill Patients (OXY-BAL). nanRECRUITING
Leukotrienes Pathway in Chinese Children With Sleep-disordered Breathing nanUNKNOWN
Fish Oil and Nonalcoholic Fatty Liver Disease (NAFLD) Study nanCOMPLETED
Investigation of the Effect of Nigella Sativa Oil and Sesame Oil in Preventing Phlebitis nanCOMPLETED
Eicosanoid Lipids by Airway Cells During Infection With Human Rhinoviruses nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a ALOX5 binder may also engage these)

ProteinNameSimilarity
P12527 — 1.000 P12527 →
P48999 — 1.000 P48999 →
P51399 — 1.000 P51399 →
O70582 — 0.990 O70582 →
Q02759 — 0.990 Q02759 →
O75342 — 0.987 O75342 →
P12530 — 0.987 P12530 →
D3ZKX9 — 0.986 D3ZKX9 →
P39654 — 0.986 P39654 →
P55249 — 0.984 P55249 →
Q2KMM4 — 0.984 Q2KMM4 →
Q9BYJ1 — 0.983 Q9BYJ1 →
P27479 — 0.982 P27479 →
Q9WV07 — 0.982 Q9WV07 →
Q5RBE8 — 0.979 Q5RBE8 →
D3ZQF9 — 0.978 D3ZQF9 →
O35936 — 0.977 O35936 →
ALOX15 Polyunsaturated fatty acid lipoxygenase ALOX15 0.977 landscape →
ALOX15B Polyunsaturated fatty acid lipoxygenase ALOX15B 0.976 landscape →
P16469 — 0.975 P16469 →
Q8K4F2 — 0.974 Q8K4F2 →
F1LQ70 — 0.972 F1LQ70 →
P39655 — 0.971 P39655 →
ALOX12 Polyunsaturated fatty acid lipoxygenase ALOX12 0.970 landscape →
Q5R5N9 — 0.968 Q5R5N9 →
Q5E9U1 — 0.968 Q5E9U1 →
Q2TV84 — 0.967 Q2TV84 →
Q4R7D0 — 0.967 Q4R7D0 →
Q803R5 — 0.967 Q803R5 →
Q58D72 — 0.967 Q58D72 →