SCHEMBL10128975

SCHEMBL10128975

C[Si](C)(C)c1ccc(/C=C/c2ccc(N)cc2)cc1

nearest known ligand 0.54

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 14/20 0.54
MAOA P21397 1/20 0.54
MAOB P27338 1/20 0.54
APP P05067 4/20 0.52
NQO2 P16083 2/20 0.47
MEN1 O00255 1/20 0.41
NPC1 O15118 1/20 0.41
MAPT P10636 1/20 0.41
CASP3 P42574 1/20 0.41
RAB9A P51151 1/20 0.41
KMT2A Q03164 1/20 0.41
ATM Q13315 1/20 0.41
SENP7 Q9BQF6 1/20 0.41
SENP6 Q9GZR1 1/20 0.41
KDM1A O60341 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8733107 0.88 NR1H2 (0.39) CYP19A1MAOAMAOBAPPMEN1
SCHEMBL8733104 0.88 NR1H2 (0.39) CYP19A1MAOAMAOBAPPMEN1
SCHEMBL1172568 0.85 MEN1 (0.50) APPMEN1NPC1MAPTRAB9A
Ethane SCHEMBL3211361 0.83 MEN1 (0.47) APPMEN1NPC1MAPTRAB9A
SCHEMBL27043327 0.83 APP (0.54) CYP19A1MAOAMAOBAPPNQO2
SCHEMBL11244660 0.80 CYP19A1 (0.78) CYP19A1MAOAMAOBAPPNQO2
SCHEMBL10459178 0.80 CYP19A1 (0.78) CYP19A1MAOAMAOBAPPNQO2
SCHEMBL7646748 0.80 CYP19A1 (0.78) CYP19A1MAOAMAOBAPPNQO2
SCHEMBL9680840 0.80 CYP19A1 (0.78) CYP19A1MAOAMAOBAPPNQO2
SCHEMBL65443 0.80 CYP19A1 (0.78) CYP19A1MAOAMAOBAPPNQO2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8785001-B2 Organic electroluminescent devices MERCK PATENT GMBH (DE) 2014-07-22 US disclosed
US-8304095-B2 Organic electroluminescent devices MERCK PATENT GMBH (DE) 2012-11-06 US disclosed
US-8207526-B2 Organic EL device IDEMITSU KOSAN CO., LTD. (JP) 2012-06-26 US disclosed
US-20100314644-A1 ORGANIC ELECTROLUMINESCENT DEVICE IDEMITSU KOSAN CO., LTD. (JP) 2010-12-16 US disclosed
US-20100044689-A1 ORGANIC EL DEVICE IDEMITSU KOSAN CO., LTD. (JP) 2010-02-25 US disclosed
US-20080297037-A1 Organic Electroluminescent Devices MERCK PATENT GMBH (DE) 2008-12-04 US disclosed
US-20080272693-A1 Organic Electroluminescent Devices MERCK PATENT GMBH (DE) 2008-11-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080272693-A1 Organic Electroluminescent Devices EML4, MT-ND4L, EPCAM CYP19A1 3419/4885MAOA 969/4885MAOB 344/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.