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Sugi Predict / Targets / EML4

EML4

Echinoderm microtubule-associated protein-like 4 · Q9HC35 · EML4 on Sugi Atlas →

23,585 patent compounds predicted against EML4, 17,580 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL283368 SCHEMBL283368 0.67 19/20
SCHEMBL283369 SCHEMBL283369 0.67 19/20
SCHEMBL282426 SCHEMBL282426 1.00 18/20
SCHEMBL282427 SCHEMBL282427 1.00 18/20
SCHEMBL282440 SCHEMBL282440 1.00 18/20
SCHEMBL282441 SCHEMBL282441 1.00 18/20
SCHEMBL282803 SCHEMBL282803 1.00 18/20
SCHEMBL282804 SCHEMBL282804 1.00 18/20
SCHEMBL282846 SCHEMBL282846 1.00 18/20
SCHEMBL282847 SCHEMBL282847 1.00 18/20
SCHEMBL283000 SCHEMBL283000 0.72 18/20
SCHEMBL283001 SCHEMBL283001 0.72 18/20
SCHEMBL282176 SCHEMBL282176 1.00 17/20
SCHEMBL282177 SCHEMBL282177 1.00 17/20
SCHEMBL282345 SCHEMBL282345 1.00 17/20
SCHEMBL282346 SCHEMBL282346 1.00 17/20
SCHEMBL282967 SCHEMBL282967 1.00 17/20
SCHEMBL282968 SCHEMBL282968 1.00 17/20
SCHEMBL283572 SCHEMBL283572 1.00 17/20
SCHEMBL283573 SCHEMBL283573 1.00 17/20

Clinical trials — most relevant to EML4 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Phase II Trial of Sequential Consolidation With Pembrolizumab Followed by Nab-paclitaxel PHASE2COMPLETED
A Study of AUY922 in Non-small-cell Lung Cancer Patients Who Have Received Previous Two Lines of Chemotherapy. PHASE2COMPLETED
Study of ABT-751 in Patients With Refractory Hematologic Malignancies PHASE1COMPLETED
Treatment Duration Increment and Pharmacodynamic Study of CX-4945 in Patients With Basal Cell Carcinoma (BCC) PHASE1COMPLETED
Research of the EML4-ALK Gene Expression in the Pleural Effusion or Tumor Tissue From Lung Cancer Patients nanUNKNOWN
Molecular Analysis of Thoracic Malignancies nanENROLLING_BY_INVITATION
The Study of Exosome EML4-ALK Fusion in NSCLC Clinical Diagnosis and Dynamic Monitoring nanUNKNOWN
Autophagy in Systemic Lupus Erythematosus nanUNKNOWN
Importance of the Microtubule Cytoskeleton in Oocyte Competence nanCOMPLETED
SBRT/RT in Oligometastatic Stage IV NSCLC nanUNKNOWN
A French Real-life Study: EvaluatioN of durvALumab Utilization and Effectiveness for First Line Extensive Stage Small Cell Lung Cancer. nanACTIVE_NOT_RECRUITING
Identification of Viable Human Embryos Using Three Different Methods nanCOMPLETED
Study of Neurodegenerative Diseases Induced Stem Cells in Patients and Healthy Family Controls. nanUNKNOWN
Derivation of New Human Embryonic Stem Cell Lines: Identification of Instructive Factors for Germ Cells Development nanUNKNOWN
Post Market Surveillance & Post Market Clinical Follow up, International, Medical Registry to Confirm the Safety and the Performance of the Anecova Intra Uterine Culture Device nanWITHDRAWN
Investigating the Role of Genetics in Disease Predisposition nanENROLLING_BY_INVITATION
The Derivation of Human Embryonic Stem Cell Lines From PGD Embryos nanRECRUITING
Crizotinib in ALK Rearranged Non-small-cell Lung Cancer nanUNKNOWN
The Role of NLRP Gene Family (NLRP1~14) in Recurrent Miscarriage and Infertility nanCOMPLETED
Gene-expression Profiles in CNS-metastatic Non-small Cell Lung Cancer nanUNKNOWN
Genetic Study of Newly Diagnosed Central Nervous System Tumors in Young Children nanCOMPLETED
Multicenter Prospective Cumulus Cell Test Study nanUNKNOWN
Influence of EMT on CTCs and Disease Progression in Prostate Cancer nanCOMPLETED
French Biological Observatory on Lung Cancer in Never Smokers nanCOMPLETED
Correlation of the Genetic Constitution of the Spent Blastocyst Media nanCOMPLETED
Non-invasive Preimplantation Genetic Testing for Aneuploidies Using Cell-free DNA in Spent Culture Media nanWITHDRAWN
Characterization of Ovarian Cancer Stem Cell nanUNKNOWN
Genetic Bases of Neuroendocrine Neoplasms in Mexican Patients nanRECRUITING
Genetic Study of Patients With Primary Ciliary Dyskinesia nanCOMPLETED
A Study Select Top-grade Embryo by Time-lapse Imaging nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a EML4 binder may also engage these)

ProteinNameSimilarity
Q3UMY5 — 1.000 Q3UMY5 →
Q6DIP5 — 1.000 Q6DIP5 →
Q2TAF3 — 0.994 Q2TAF3 →
Q5RE88 — 0.992 Q5RE88 →
Q84JM4 — 0.991 Q84JM4 →
Q8K3E5 — 0.990 Q8K3E5 →
Q6GM71 — 0.990 Q6GM71 →
Q5NBT9 — 0.990 Q5NBT9 →
O17468 — 0.990 O17468 →
RBBP5 Retinoblastoma-binding protein 5 0.990 landscape →
Q8BX09 — 0.989 Q8BX09 →
B7FF12 — 0.989 B7FF12 →
Q2HJE1 — 0.989 Q2HJE1 →
Q9LRZ0 — 0.989 Q9LRZ0 →
O13046 — 0.988 O13046 →
B4F7L9 — 0.988 B4F7L9 →
A0A2R8QPS5 — 0.988 A0A2R8QPS5 →
WDR91 WD repeat-containing protein 91 0.988 landscape →
Q7TMQ7 — 0.988 Q7TMQ7 →
B7FF07 — 0.988 B7FF07 →
NFKB1 Nuclear factor NF-kappa-B p105 subunit 0.988 landscape →
Q27GK7 — 0.988 Q27GK7 →
Q7Z3E5 — 0.988 Q7Z3E5 →
Q9D565 — 0.987 Q9D565 →
Q8TBY9 — 0.987 Q8TBY9 →
Q6ZJW8 — 0.987 Q6ZJW8 →
Q8BX57 — 0.987 Q8BX57 →
O54774 — 0.987 O54774 →
Q7Z401 — 0.987 Q7Z401 →
O00423 — 0.987 O00423 →