Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 4/20 | 0.50 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 4/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 4/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 3/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | SQSTM1 | Q13501 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27919116 | 0.89 | IDO1 (0.47) | IDO1CNR2KEAP1NFE2L2SLC2A1 | |
| SCHEMBL27937795 | 0.86 | LIPG (0.45) | IDO1CNR2KDM4EALDH1A1GAA | |
| SCHEMBL28805669 | 0.86 | LIPG (0.45) | IDO1CNR2KDM4EALDH1A1GAA | |
| SCHEMBL27937845 | 0.84 | IDO1 (0.53) | IDO1KEAP1NFE2L2GAASQSTM1 | |
| SCHEMBL798769 | 0.83 | KDM4E (0.46) | CNR2KDM4EALDH1A1GAAHPGD | |
| SCHEMBL30537733 | 0.83 | KDM4E (0.46) | CNR2KDM4EALDH1A1GAAHPGD | |
| SCHEMBL1555794 | 0.80 | GAA (0.55) | IDO1KDM4EALDH1A1GAAHPGD | |
| SCHEMBL9778189 | 0.78 | IDO1 (0.73) | IDO1KEAP1NFE2L2KDM4EALDH1A1 | |
| SCHEMBL30336868 | 0.78 | IDO1 (0.73) | IDO1KEAP1NFE2L2KDM4EALDH1A1 | |
| SCHEMBL27937946 | 0.78 | IDO1 (0.39) | IDO1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8114873-B2 | 1,4-disubstituted naphthalenes as inhibitors of p38 map kinase | ARQULE, INC. (US) | 2012-02-14 | — | — | US | disclosed |
| US-20100311754-A1 | 1,4-Disubstituted Naphthalenes as Inhibitors of P38 Map Kinase | ARQULE, INC. (US) | 2010-12-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100311754-A1 | 1,4-Disubstituted Naphthalenes as Inhibitors of P38 Map Kinase | MAPK1, MAPK7, MAP3K1 | IDO1 698/4885CHRNB2 4056/4885CHRNA7 3947/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.