Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 18/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | PDE6D | O43924 | 1/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | HMGCR | P04035 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14045937 | 0.89 | GCGR (0.54) | GCGRALDH1A1CYP3A4PDE6DNR1I2 | |
| SCHEMBL10129495 | 0.87 | GCGR (0.43) | GCGRALDH1A1CYP3A4PDE6DNR1I2 | |
| SCHEMBL20146246 | 0.87 | GCGR (0.43) | GCGRALDH1A1CYP3A4PDE6DNR1I2 | |
| SCHEMBL20146255 | 0.85 | GCGR (0.41) | GCGRALDH1A1CYP3A4PDE6DNR1I2 | |
| SCHEMBL10434301 | 0.84 | GCGR (0.41) | GCGRALDH1A1CYP3A4PDE6DNR1I2 | |
| SCHEMBL29482554 | 0.84 | HMGCR (0.58) | GCGRALDH1A1CYP3A4PDE6DNR1I2 | |
| SCHEMBL2690 | 0.84 | HMGCR (0.58) | GCGRALDH1A1CYP3A4PDE6DNR1I2 | |
| SCHEMBL10129253 | 0.84 | GCGR (0.45) | GCGRALDH1A1CYP3A4PDE6DNR1I2 | |
| SCHEMBL15024689 | 0.83 | GCGR (0.49) | GCGRALDH1A1CYP3A4PDE6DNR1I2 | |
| SCHEMBL8204817 | 0.82 | GCGR (0.48) | GCGRALDH1A1CYP3A4PDE6DNR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2423195-A1 | Process for the preparation of key intermediates for the synthesis of statins or pharmaceutically acceptable salts thereof | LEK Pharmaceuticals d.d. (SI) | 2012-02-29 | — | — | EP | disclosed |
| WO-2012013325-A1 | PROCESS FOR THE PREPARATION OF KEY INTERMEDIATES FOR THE SYNTHESIS OF STATINS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF | LEK PHARMACEUTICALS D.D. (SI) | 2012-02-02 | — | — | WO | disclosed |
| EP-0367895-A1 | Pyrimidinyl-substituted hydroxyacids, lactones and esters and pharmaceutical compositions containing them | SANDOZ AG (CH) | 1990-05-16 | — | — | EP | disclosed |