Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.41 |
| ▸ | GCGR | P47871 | 11/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HMGCR | P04035 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | PDE6D | O43924 | 1/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.37 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13637067 | 0.88 | KDM5B (0.40) | KDM5BGCGRALDH1A1HMGCRCYP3A4 | |
| SCHEMBL6747778 | 0.86 | GCGR (0.41) | KDM5BGCGRALDH1A1HMGCRCYP3A4 | |
| SCHEMBL10129494 | 0.85 | GCGR (0.46) | GCGRALDH1A1HMGCRCYP3A4PDE6D | |
| SCHEMBL6804623 | 0.84 | HMGCR (0.55) | KDM5BALDH1A1HMGCRCYP3A4PDE6D | |
| SCHEMBL10129501 | 0.84 | HMGCR (0.38) | GCGRALDH1A1HMGCRCYP3A4PDE6D | |
| SCHEMBL10129522 | 0.82 | GCGR (0.57) | GCGRALDH1A1HMGCRCYP3A4PDE6D | |
| SCHEMBL20146246 | 0.81 | GCGR (0.43) | GCGRALDH1A1HMGCRCYP3A4PDE6D | |
| SCHEMBL10129495 | 0.81 | GCGR (0.43) | GCGRALDH1A1HMGCRCYP3A4PDE6D | |
| SCHEMBL10129258 | 0.80 | HMGCR (0.47) | GCGRALDH1A1HMGCRCYP3A4PDE6D | |
| SCHEMBL10434011 | 0.79 | HMGCR (0.44) | GCGRALDH1A1HMGCRCYP3A4PDE6D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2423195-A1 | Process for the preparation of key intermediates for the synthesis of statins or pharmaceutically acceptable salts thereof | LEK Pharmaceuticals d.d. (SI) | 2012-02-29 | — | — | EP | disclosed |
| WO-2012013325-A1 | PROCESS FOR THE PREPARATION OF KEY INTERMEDIATES FOR THE SYNTHESIS OF STATINS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF | LEK PHARMACEUTICALS D.D. (SI) | 2012-02-02 | — | — | WO | disclosed |