SCHEMBL10129753

SCHEMBL10129753

COC(=O)c1c(Cl)cc(C)cc1Cl

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.47
KDM4E B2RXH2 1/20 0.47
GLA P06280 1/20 0.47
HSD17B10 Q99714 1/20 0.47
CYP3A4 P08684 2/20 0.46
ACHE P22303 1/20 0.46
GLO1 Q04760 1/20 0.45
MAPT P10636 2/20 0.44
CA12 O43570 1/20 0.43
CA1 P00915 1/20 0.43
CA2 P00918 1/20 0.43
CA7 P43166 1/20 0.43
CA9 Q16790 1/20 0.43
CA14 Q9ULX7 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
KMT2A Q03164 3/20 0.43
HPGD P15428 1/20 0.43
GAA P10253 3/20 0.42
ALDH1A1 P00352 3/20 0.42
LMNA P02545 3/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22754120 0.90 CYP3A4 (0.50) TSHRKDM4EGLAHSD17B10CYP3A4
SCHEMBL8574153 0.87 GAA (0.46) TSHRKDM4EGLAHSD17B10CYP3A4
SCHEMBL5787779 0.85 NOTUM (0.43) TSHRKDM4EGLAHSD17B10CYP3A4
SCHEMBL5542753 0.84 KMT2A (0.53) TSHRKDM4EGLAHSD17B10CYP3A4
SCHEMBL522606 0.83 CA1 (0.54) TSHRKDM4EMAPTCA12CA1
SCHEMBL5786874 0.83 CYP3A4 (0.55) TSHRKDM4EGLAHSD17B10CYP3A4
SCHEMBL22212072 0.82 TSHR (0.39) TSHRKDM4EGLAHSD17B10CYP3A4
SCHEMBL879309 0.81 CA12 (0.42) TSHRKDM4EGLAHSD17B10CYP3A4
SCHEMBL1707046 0.81 NQO2 (0.50) TSHRKDM4EGLAHSD17B10CYP3A4
SCHEMBL7282028 0.81 CYP3A4 (0.55) TSHRKDM4EGLAHSD17B10CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11325929-B2 Phosphorus-containing compound and preparation and use thereof VIVAVISIONSHANGHAILTD (CN) 2022-05-10 US disclosed
US-20200131206-A1 PHOSPHORUS-CONTAINING COMPOUND AND PREPARATION AND USE THEREOF VIVAVISIONSHANGHAILTD (CN) 2020-04-30 US disclosed
US-20160074381-A1 MODULATORS OF CELLULAR ADHESION SARCODE BIOSCIENCE INC. (US) 2016-03-17 US disclosed
US-9248126-B2 Modulators of cellular adhesion SARCODE BIOSCIENCE INC. (US) 2016-02-02 US disclosed
US-9216174-B2 Modulators of cellular adhesion SARCODE BIOSCIENCE INC. (US) 2015-12-22 US disclosed
US-20140066476-A1 MODULATORS OF CELLULAR ADHESION SARCODE BIOSCIENCE INC. (US) 2014-03-06 US disclosed
US-20140051675-A1 MODULATORS OF CELLULAR ADHESION SARCODE BIOSCIENCE INC. (US) 2014-02-20 US disclosed
US-20120035154-A1 Modulators of Cellular Adhesion SARcode Bioscience, Inc. (US) 2012-02-09 US disclosed
US-8071617-B2 Modulators of cellular adhesion SARCODE BIOSCIENCE INC. (US) 2011-12-06 US disclosed
US-7989626-B2 Modulators of cellular adhesion SAR code Corporation (US) 2011-08-02 US disclosed
US-20110124669-A1 Modulators of Cellular Adhesion SARCODE CORPORATION (US) 2011-05-26 US disclosed
US-20110124625-A1 Modulators of Cellular Adhesion SARCODE CORPORATION (US) 2011-05-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140066476-A1 MODULATORS OF CELLULAR ADHESION ITGB1, VCAM1, ITGB8 TSHR 1857/4885KDM4E 3313/4885GLA 3762/4885
US-20140051675-A1 MODULATORS OF CELLULAR ADHESION ITGB1, VCAM1, ITGB8 TSHR 1857/4885KDM4E 3313/4885GLA 3762/4885
US-11325929-B2 Phosphorus-containing compound and preparation and use thereof INPP5D, CXCL12, INPPL1 TSHR 2839/4885KDM4E 3198/4885GLA 1891/4885
US-20110124625-A1 Modulators of Cellular Adhesion ITGB1, VCAM1, ITGB8 TSHR 1857/4885KDM4E 3313/4885GLA 3762/4885
US-20160074381-A1 MODULATORS OF CELLULAR ADHESION ITGB1, VCAM1, ITGB8 TSHR 1857/4885KDM4E 3313/4885GLA 3762/4885
US-20110124669-A1 Modulators of Cellular Adhesion ITGB1, VCAM1, ITGB8 TSHR 1857/4885KDM4E 3313/4885GLA 3762/4885
US-20120035154-A1 Modulators of Cellular Adhesion ITGB1, VCAM1, ITGB8 TSHR 1857/4885KDM4E 3313/4885GLA 3762/4885
US-20200131206-A1 PHOSPHORUS-CONTAINING COMPOUND AND PREPARATION AND USE THEREOF INPP5D, CXCL12, INPPL1 TSHR 2839/4885KDM4E 3198/4885GLA 1891/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.