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Sugi Predict / Targets / VCAM1

VCAM1

Vascular cell adhesion protein 1 · P19320 · VCAM1 on Sugi Atlas →

30,405 patent compounds predicted against VCAM1, 15,651 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL376610 SCHEMBL376610 0.71 18/20
SCHEMBL176738 SCHEMBL176738 0.69 18/20
SCHEMBL332971 SCHEMBL332971 0.69 17/20
SCHEMBL176739 SCHEMBL176739 0.67 17/20
SCHEMBL257727 SCHEMBL257727 0.56 16/20
Succinobucol Succinobucol (SCHEMBL347492) 1.00 14/20
SCHEMBL237370 SCHEMBL237370 0.51 14/20
SCHEMBL241620 SCHEMBL241620 0.51 14/20
SCHEMBL627966 SCHEMBL627966 0.51 14/20
SCHEMBL273093 SCHEMBL273093 0.43 14/20
Probucol Probucol (SCHEMBL4150) 0.60 13/20
SCHEMBL541080 SCHEMBL541080 0.59 13/20
SCHEMBL539833 SCHEMBL539833 0.56 12/20
SCHEMBL6463 SCHEMBL6463 1.00 11/20
SCHEMBL84100 SCHEMBL84100 0.56 11/20
SCHEMBL213965 SCHEMBL213965 0.56 11/20
SCHEMBL373869 SCHEMBL373869 0.51 11/20
SCHEMBL38445 SCHEMBL38445 0.60 10/20
SCHEMBL100583 SCHEMBL100583 0.50 10/20
SCHEMBL237358 SCHEMBL237358 0.50 10/20

Clinical trials — most relevant to VCAM1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Effect of Glucose Degradation Products (GDP) on Endothelial Dysfunction PHASE4COMPLETED
Simvastatin Reduces Circulating Osteoprotegerin Levels in Patients With Type 2 Diabetes PHASE4COMPLETED
Atorvastatin in Acute Stroke Treatment PHASE4COMPLETED
A Study to Evaluate Efficacy, of Early Versus Late Use of Vedolizumab in Crohn's Disease: the LOVE-CD Study PHASE4COMPLETED
Effect of a Multidomain Intervention Plus Turmeric on the Prevention of Cognitive Decline in People Over 55 Years of Age With Insulin Resistance. PHASE2/PHASE3ACTIVE_NOT_RECRUITING
Effect of Pentoxifylline on Endothelial Dysfunction in Patients With Acute Coronary Syndrome PHASE2/PHASE3COMPLETED
PLASMA Trial: A Dose-Response Study of A-002 In Subjects With Stable Coronary Artery Disease PHASE2COMPLETED
PLASMA 2 Trial: Examination of Once Daily (QD) Dosing of A-002 In Subjects With Stable Coronary Artery Disease PHASE2COMPLETED
Effects of Angiotensin-Converting Enzyme Inhibitor (Ramipril) Therapy on Blood Vessel Inflammation PHASE2COMPLETED
Defibrotide in COVID-19 Pneumonia PHASE2COMPLETED
Pembrolizumab and Induction Chemotherapy in Head and Neck Squamous Cell Carcinoma (PICH Study) PHASE1/PHASE2WITHDRAWN
Prospective Comparison of the Effect on Antiadhesive Barriers During Thyroid Surgery PHASE1COMPLETED
Combined aPproach to Treatment Using Ranibizumab and Efalizumab for Diabetic Macular Edema Study: The CAPTURE DME Study PHASE1WITHDRAWN
A Pilot Study of the Mechanism of Synergism Between FP and Salmeterol in Preventing COPD Exacerbations PHASE1COMPLETED
Comparing The Effect of Tadalafil 5 mg/Day to Sildenafil 25 mg/Day on Neutrophil-Lymphocyte and Platelet-Lymphocyte Ratios in Erectile Dysfunction Patients; and Comparison of Clinical Response EARLY_PHASE1UNKNOWN
Abdominal Aortic Aneurysm Surgery and Thrombosis nanCOMPLETED
Biodistribution, Dosimetry and Performance of [68Ga]Ga-DOTA-Siglec-9 in Healthy and Patients With Rheumatoid Arthritis, Vasculitis or Pulmonary Sarcoidosis nanENROLLING_BY_INVITATION
Effects of Short-term Curcumin and Multi-polyphenol Supplementation on the Anti-inflammatory Properties of HDL nanCOMPLETED
Pilot Study of Bevacizumab (Avastin) in Patients With Septic Shock nanWITHDRAWN
Endothelial Dysfunction and Selenium Status in Children With Acute Systemic Inflammatory Response nanCOMPLETED
Soluble Receptors for Advanced Glycation End-Products and PCI nanUNKNOWN
Microcirculation and Bone Metabolism in Patients With Type 2 Diabetes Mellitus and Charcot Foot - A Pilot Study nanCOMPLETED
Indoxyl Sulfate Induces Leukocyte-endothelial Interactions Through Up-regulation of ICAM-1 in Acute Kidney Injury nanUNKNOWN
Do Omega-3 Fatty Acids Have an Antidepressant Effect in Patients With Signs of Peripheral Inflammation? nanCOMPLETED
Von Willebrand Antigen and Activity as Novel Biomarkers of Hemostasis in Inflammatory Bowel Disease nanUNKNOWN
Role of Endothelial Cells in the Pathogenesis of Chronic Urticaria. nanUNKNOWN
Role of CD11a in Pathogenesis of Primary ITP and Effect of Immunosuppressive Therapy on Its Level nanCOMPLETED
Noninvasive Predictors of Transplant Vasculopathy nanWITHDRAWN
Noninvasive Evaluation of Cardiac Allograft Vasculopathy nanWITHDRAWN
Microbiota in COVID-19 Patients for Future Therapeutic and Preventive Approaches nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a VCAM1 binder may also engage these)

ProteinNameSimilarity
Q28260 — 0.999 Q28260 →
P29533 — 0.998 P29533 →
P29534 — 0.997 P29534 →
Q13740 — 0.982 Q13740 →
Q9BH13 — 0.981 Q9BH13 →
Q61490 — 0.979 Q61490 →
O35112 — 0.979 O35112 →
Q3SWT0 — 0.977 Q3SWT0 →
P51866 — 0.977 P51866 →
O46634 — 0.977 O46634 →
P42292 — 0.977 P42292 →
P16284 — 0.977 P16284 →
Q95242 — 0.976 Q95242 →
O46651 — 0.976 O46651 →
Q08481 — 0.974 Q08481 →
Q6DJ83 — 0.974 Q6DJ83 →
P23085 — 0.973 P23085 →
P04218 — 0.971 P04218 →
Q501W4 — 0.971 Q501W4 →
Q9N1E5 — 0.971 Q9N1E5 →
P35329 — 0.971 P35329 →
Q9N1E4 — 0.971 Q9N1E4 →
Q9EPF2 — 0.970 Q9EPF2 →
CD22 B-cell receptor CD22 0.970 landscape →
P23086 — 0.970 P23086 →
P97710 — 0.970 P97710 →
Q9N1E6 — 0.970 Q9N1E6 →
Q8R2Y2 — 0.970 Q8R2Y2 →
P23088 — 0.969 P23088 →
P43121 — 0.969 P43121 →