Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | TLR9 | Q9NR96 | 4/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.41 |
| ▸ | MGMT | P16455 | 7/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.37 |
| ▸ | CDK1 | P06493 | 2/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.36 |
| ▸ | CDK2 | P24941 | 2/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1566667 | 0.87 | POLB (0.53) | POLBTLR9TLR7FGFR1SLC22A6 | |
| SCHEMBL1567138 | 0.85 | POLB (0.54) | POLBTLR9TLR7FGFR1SLC22A6 | |
| SCHEMBL1565444 | 0.83 | POLB (0.54) | POLBFGFR1SLC22A6 | |
| SCHEMBL1565570 | 0.81 | POLB (0.55) | POLBFGFR1SLC22A6 | |
| SCHEMBL17625500 | 0.81 | POLB (0.44) | POLBTLR9TLR7MGMTCDK1 | |
| SCHEMBL13747170 | 0.80 | POLB (0.40) | POLBTLR9TLR7MGMTCDK1 | |
| SCHEMBL13746589 | 0.77 | MGMT (0.43) | POLBTLR9TLR7MGMTCDK1 | |
| SCHEMBL2607076 | 0.77 | POLB (0.46) | POLBTLR9TLR7FGFR1SLC22A6 | |
| SCHEMBL13747659 | 0.77 | POLB (0.39) | POLBTLR9TLR7MGMTCDK1 | |
| SCHEMBL10129543 | 0.76 | CDK1 (0.46) | POLBTLR9TLR7MGMTADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163718-B2 | Nucleoside analogues containing phosphonate or phosphonamide groups | GILEAD SCIENCES, INC. (US) | 2012-04-24 | — | — | US | disclosed |
| EP-2308885-A2 | Novel compounds and methods for therapy | Gilead Sciences, Inc. (US) | 2011-04-13 | — | — | EP | disclosed |
| US-20090232768-A1 | NOVEL COMPOUNDS AND METHODS FOR THERAPY | GILEAD SCIENCES, INC. (US) | 2009-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090232768-A1 | NOVEL COMPOUNDS AND METHODS FOR THERAPY | TP53, ZC3HAV1, ZFX | POLB 501/4885TLR9 1407/4885TLR7 1639/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.