Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGMT | P16455 | 7/20 | 0.43 |
| ▸ | POLB | P06746 | 4/20 | 0.42 |
| ▸ | CDK1 | P06493 | 3/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.41 |
| ▸ | CDK2 | P24941 | 3/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | POLA1 | P09884 | 1/20 | 0.38 |
| ▸ | POLG | P54098 | 1/20 | 0.38 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10129543 | 0.87 | CDK1 (0.46) | MGMTPOLBCDK1CCNB1CCNE1 | |
| SCHEMBL2091750 | 0.86 | FGFR1 (0.57) | POLBFGFR1SLC22A6POLA1POLG | |
| SCHEMBL24383709 | 0.78 | HSP90AB1 (0.51) | MGMTPOLBCDK1CCNB1CCNE1 | |
| SCHEMBL10129844 | 0.77 | POLB (0.43) | MGMTPOLBCDK1CCNB1CCNE1 | |
| SCHEMBL1565558 | 0.77 | FGFR1 (0.57) | POLBCDK1CCNB1CCNE1CDK2 | |
| SCHEMBL1567494 | 0.77 | FGFR1 (0.60) | POLBHSP90AA1HSP90AB1FGFR1SLC22A6 | |
| SCHEMBL30824623 | 0.77 | FGFR1 (0.60) | POLBHSP90AA1HSP90AB1FGFR1SLC22A6 | |
| SCHEMBL1565553 | 0.77 | FGFR1 (0.56) | POLBCDK1CCNB1CCNE1CDK2 | |
| SCHEMBL2606987 | 0.76 | POLB (0.44) | POLBCDK1CCNB1CCNE1CDK2 | |
| SCHEMBL18665409 | 0.76 | HSP90AA1 (0.47) | MGMTPOLBCDK1CCNB1CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009105513-A2 | NOVEL COMPOUNDS AND METHODS FOR THERAPY | GILEAD SCIENCES, INC. (US) | 2009-08-27 | — | — | WO | disclosed |