Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 16/20 | 0.43 |
| ▸ | MAP3K20 | Q9NYL2 | 6/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.37 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10129951 | 0.92 | BRAF (0.41) | BRAFMAP3K20RAF1LCKLIMK1 | |
| SCHEMBL10129575 | 0.87 | BRAF (0.51) | BRAFMAP3K20RAF1LCKLIMK1 | |
| SCHEMBL10129570 | 0.87 | BRAF (0.43) | BRAFMAP3K20RAF1LCKLIMK1 | |
| SCHEMBL16573187 | 0.86 | BRAF (0.50) | BRAFMAP3K20RAF1LCKLIMK1 | |
| SCHEMBL16573185 | 0.86 | BRAF (0.45) | BRAFMAP3K20RAF1 | |
| SCHEMBL16573205 | 0.84 | BRAF (0.45) | BRAFMAP3K20RAF1 | |
| SCHEMBL16573221 | 0.81 | BRAF (0.43) | BRAFMAP3K20RAF1 | |
| SCHEMBL16573249 | 0.80 | BRAF (0.47) | BRAFMAP3K20LCKLIMK1LIMK2 | |
| SCHEMBL16573188 | 0.79 | BRAF (0.42) | BRAFMAP3K20 | |
| SCHEMBL16573198 | 0.79 | BRAF (0.47) | BRAFMAP3K20LCKLIMK1LIMK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085127-A1 | NEW TRIAZOLYLPHENYL SULFONAMIDES AS SERINE/THREONINE KINASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-28 | — | — | WO | disclosed |