Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 18/20 | 0.43 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | MAP3K20 | Q9NYL2 | 4/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16573205 | 0.92 | BRAF (0.45) | BRAFRAF1MAP3K20 | |
| SCHEMBL16573185 | 0.92 | BRAF (0.45) | BRAFRAF1MAP3K20 | |
| SCHEMBL16573197 | 0.88 | BRAF (0.39) | BRAFRAF1MAP3K20 | |
| SCHEMBL16573198 | 0.88 | BRAF (0.47) | BRAFMAP3K20 | |
| SCHEMBL10129951 | 0.85 | BRAF (0.41) | BRAFRAF1MAP3K20 | |
| SCHEMBL10129575 | 0.84 | BRAF (0.51) | BRAFRAF1MAP3K20 | |
| SCHEMBL16573187 | 0.84 | BRAF (0.50) | BRAFRAF1MAP3K20 | |
| SCHEMBL16573189 | 0.83 | BRAF (0.43) | BRAFMAP3K20 | |
| SCHEMBL16573249 | 0.81 | BRAF (0.47) | BRAFMAP3K20 | |
| SCHEMBL10129950 | 0.81 | BRAF (0.43) | BRAFRAF1MAP3K20 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655355-B1 | NEW TRIAZOLYLPHENYL SULFONAMIDES AS SERINE/THREONINE KINASE INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2015-03-18 | — | — | EP | disclosed |