Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 7/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.39 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10130018 | 0.89 | S1PR2 (0.50) | LCKSCN9AS1PR2BRD9GSK3B | |
| SCHEMBL20355063 | 0.86 | LCK (0.49) | LCKSCN9ABRD9GSK3BDYRK1A | |
| SCHEMBL10130001 | 0.85 | SCN9A (0.43) | LCKSCN9AS1PR2BRD9GSK3B | |
| SCHEMBL2113744 | 0.82 | LCK (0.51) | LCKNOS3NOS2CHRNB2CHRNB4 | |
| SCHEMBL30711674 | 0.82 | LCK (0.51) | LCKNOS3NOS2CHRNB2CHRNB4 | |
| SCHEMBL30592890 | 0.79 | LCK (0.44) | LCKSCN9ABRD9GSK3BDYRK1A | |
| SCHEMBL13727420 | 0.79 | LCK (0.44) | LCKSCN9ABRD9GSK3BDYRK1A | |
| SCHEMBL13983675 | 0.79 | LCK (0.44) | LCKSCN9AMAPKAPK2NOS3NOS2 | |
| SCHEMBL20355066 | 0.79 | SCN9A (0.46) | LCKSCN9AMAPKAPK2GSK3BDYRK1A | |
| SCHEMBL4076010 | 0.78 | CHRNB2 (0.51) | LCKSCN9AMAPKAPK2CHRNB2CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120028970-A1 | HETEROARYLTHIOMETHYL PYRIDINE DERIVATIVE | MSD K.K. (JP) | 2012-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028970-A1 | HETEROARYLTHIOMETHYL PYRIDINE DERIVATIVE | AR, NR5A1, ARL1 | LCK 3488/4885SCN9A 3772/4885MAPKAPK2 2901/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.