Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.48 |
| ▸ | TGFBR1 | P36897 | 8/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.38 |
| ▸ | SMAD2 | Q15796 | 1/20 | 0.38 |
| ▸ | VRK1 | Q99986 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1011935 | 0.99 | DYRK1A (0.47) | DYRK1ATGFBR1NPC1RAB9ANTRK1 | |
| SCHEMBL3910228 | 0.79 | DYRK1A (0.41) | DYRK1ATGFBR1NTRK1NTRK2ADORA2A | |
| Hydrochloric Acid SCHEMBL4532456 | 0.79 | DYRK1A (0.54) | DYRK1ATGFBR1NPC1RAB9ABMPR1A | |
| SCHEMBL761993 | 0.73 | MEN1 (0.52) | DYRK1ATGFBR1NPC1RAB9ANTRK1 | |
| SCHEMBL12954688 | 0.72 | TRPV1 (0.44) | DYRK1ANTRK1NTRK2KDR | |
| SCHEMBL22270818 | 0.68 | ADORA2B (0.50) | DYRK1ATGFBR1NPC1RAB9AADORA2A | |
| SCHEMBL30945399 | 0.68 | DYRK1A (0.56) | DYRK1ATGFBR1BMPR1ASMAD2VRK1 | |
| SCHEMBL18589865 | 0.68 | FFAR1 (0.45) | DYRK1ATGFBR1NTRK1NTRK2MEN1 | |
| SCHEMBL27631450 | 0.68 | NPC1 (0.54) | NPC1RAB9AADORA2AKMT2ADHFR | |
| SCHEMBL6473464 | 0.68 | ADORA2A (0.41) | DYRK1ATGFBR1NPC1RAB9ANTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1542692-B1 | AMINOPYRIMIDINE DERIVATIVES FOR USE AS VANILLOID RECEPTOR LIGANDS FOR THE TREATMENT OF PAIN | AMGEN INC (US) | 2011-01-05 | — | — | EP | claimed |