Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 10/20 | 0.62 |
| ▸ | F2 | P00734 | 1/20 | 0.50 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.50 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.50 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NSD2 | O96028 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10132109 | 0.82 | EDNRA (0.58) | EDNRAF2PRSS1PRSS2PRSS3 | |
| SCHEMBL10132112 | 0.78 | EDNRA (0.53) | EDNRAF2PRSS1PRSS2PRSS3 | |
| SCHEMBL13713919 | 0.76 | F2 (0.62) | EDNRAF2PRSS1PRSS2PRSS3 | |
| SCHEMBL10132113 | 0.76 | EDNRA (0.50) | EDNRAF2PRSS1PRSS2PRSS3 | |
| SCHEMBL15480547 | 0.75 | EDNRA (0.71) | EDNRAHDAC4HDAC10HDAC6HDAC5 | |
| SCHEMBL15047790 | 0.75 | ALDH1A1 (0.48) | EDNRAALDH1A1POLBTDP1HDAC4 | |
| SCHEMBL10132117 | 0.74 | EDNRA (0.53) | EDNRAF2PRSS1PRSS2PRSS3 | |
| SCHEMBL10122106 | 0.73 | F2 (0.49) | EDNRAF2PRSS1PRSS2PRSS3 | |
| SCHEMBL11406892 | 0.72 | EDNRA (0.63) | EDNRAF2PRSS1PRSS2PRSS3 | |
| SCHEMBL11402938 | 0.72 | EDNRA (0.63) | EDNRAF2PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130158063-A1 | Compounds, Compositions and Methods Related to PPAR Antagonists | GEORGETOWN UNIVERSITY (US) | 2013-06-20 | — | — | US | disclosed |
| WO-2012027482-A2 | COMPOUNDS, COMPOSITIONS AND METHODS RELATED TO PPAR ANTAGONISTS | GEORGETOWN UNIVERSITY (US) | 2012-03-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130158063-A1 | Compounds, Compositions and Methods Related to PPAR Antagonists | PPARG, PPARA, PPARD | EDNRA 902/4885F2 3352/4885PRSS1 2879/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.