Sugi Predict

Sugi Predict / Compounds / SCHEMBL10132344

SCHEMBL10132344

SCHEMBL10132344

CC(C)(C)OC(=O)N1CCC[C@H]1C(O)c1ccc(F)c(F)c1

nearest known ligand 0.47

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ NR1H2 P55055 2/20 0.47
▸ NR1H3 Q13133 2/20 0.47
▸ LMNA P02545 1/20 0.43
▸ NPSR1 Q6W5P4 1/20 0.43
▸ ALDH1A1 P00352 2/20 0.43
▸ MEN1 O00255 2/20 0.43
▸ KMT2A Q03164 2/20 0.43
▸ NPC1 O15118 2/20 0.43
▸ HSD17B10 Q99714 1/20 0.42
▸ F2R P25116 1/20 0.40
▸ L3MBTL1 Q9Y468 2/20 0.40
▸ UCHL1 P09936 2/20 0.40
▸ MAPT P10636 1/20 0.40
▸ MAPK1 P28482 1/20 0.40
▸ HTT P42858 1/20 0.40
▸ RAB9A P51151 1/20 0.40
▸ DPP4 P27487 1/20 0.40
▸ KLK7 P49862 1/20 0.38
▸ USP30 Q70CQ3 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2475987 0.91 LMNA (0.47) NR1H2NR1H3LMNANPSR1ALDH1A1
SCHEMBL10132391 0.90 F2R (0.47) NR1H2NR1H3LMNANPSR1ALDH1A1
SCHEMBL15260288 0.90 F2R (0.47) NR1H2NR1H3LMNANPSR1ALDH1A1
SCHEMBL15260287 0.90 F2R (0.47) NR1H2NR1H3LMNANPSR1ALDH1A1
SCHEMBL10132308 0.90 F2R (0.47) NR1H2NR1H3LMNANPSR1ALDH1A1
SCHEMBL15260286 0.90 F2R (0.47) NR1H2NR1H3LMNANPSR1ALDH1A1
SCHEMBL16583074 0.89 NR1H2 (0.42) NR1H2NR1H3LMNANPSR1ALDH1A1
SCHEMBL16583076 0.89 NR1H2 (0.42) NR1H2NR1H3LMNANPSR1ALDH1A1
SCHEMBL16583073 0.89 NR1H2 (0.42) NR1H2NR1H3LMNANPSR1ALDH1A1
SCHEMBL10132244 0.87 MEN1 (0.43) NR1H2NR1H3LMNANPSR1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2374794-B1 CYCLIC AMINE COMPOUNDS DAIICHI SANKYO CO LTD (JP) 2015-11-04 — — EP disclosed
US-8173631-B2 Cyclic amine compounds DAIICHI SANKYO COMPANY, LIMITED (JP) 2012-05-08 — — US disclosed
US-8173631-B2 Cyclic amine compounds DAIICHI SANKYO COMPANY, LIMITED (JP) 2012-05-08 — — US disclosed
US-20110319468-A1 CYCLIC AMINE COMPOUNDS DAIICHI SANKYO COMPANY, LIMITED (JP) 2011-12-29 — — US disclosed
US-20110319468-A1 CYCLIC AMINE COMPOUNDS DAIICHI SANKYO COMPANY, LIMITED (JP) 2011-12-29 — — US disclosed
EP-2374794-A1 CYCLIC AMINE COMPOUNDS Daiichi Sankyo Company, Limited (JP) 2011-10-12 — — EP disclosed
WO-2010074088-A1 CYCLIC AMINE COMPOUNDS 第一三共株式会社 (JP) 2010-07-01 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110319468-A1 CYCLIC AMINE COMPOUNDS RYR2, CASR, RYR1 NR1H2 576/4885NR1H3 763/4885LMNA 2492/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.