Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | CNR2 | P34972 | 10/20 | 0.45 |
| ▸ | CNR1 | P21554 | 5/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.44 |
| ▸ | RAF1 | P04049 | 2/20 | 0.43 |
| ▸ | BRAF | P15056 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9958632 | 0.88 | ALDH1A1 (0.50) | ALDH1A1CNR2CNR1MAPK14 | |
| SCHEMBL2635371 | 0.82 | ALDH1A1 (0.71) | ALDH1A1CNR2CNR1MAPK14RAF1 | |
| SCHEMBL1013308 | 0.81 | RAF1 (0.47) | ALDH1A1MAPK14RAF1BRAF | |
| SCHEMBL9958104 | 0.80 | CNR2 (0.58) | ALDH1A1CNR2CNR1MAPK14 | |
| SCHEMBL1698936 | 0.74 | EGFR (0.50) | MAPK14RAF1BRAFSMN1; SMN2 | |
| SCHEMBL26789822 | 0.72 | ALDH1A1 (0.53) | ALDH1A1CNR2CNR1MAPK14SMN1; SMN2 | |
| SCHEMBL25793081 | 0.71 | ALDH1A1 (0.55) | ALDH1A1CNR2CNR1MAPK14SMN1; SMN2 | |
| SCHEMBL1896996 | 0.71 | ALDH1A1 (0.66) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL25288005 | 0.70 | ALDH1A1 (0.47) | ALDH1A1MAPK14SMN1; SMN2 | |
| SCHEMBL9893018 | 0.69 | ALDH1A1 (0.71) | ALDH1A1CNR2CNR1MAPK14RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2268623-A1 | QUINAZOLINE DERIVATIVES AS RAF KINASE MODULATORS AND METHODS OF USE THEREOF | Ambit Biosciences Corporation (US) | 2011-01-05 | — | — | EP | disclosed |
| WO-2009117080-A1 | QUINAZOLINE DERIVATIVES AS RAF KINASE MODULATORS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATON (US) | 2009-09-24 | — | — | WO | disclosed |