Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 7/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | WDR5 | P61964 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10115290 | 1.00 | HDAC3 (0.46) | HDAC3HDAC1ALDH1A1HPGDKMT2A | |
| SCHEMBL10115300 | 0.88 | KMT2A (0.38) | HDAC3HDAC1ALDH1A1HPGDKMT2A | |
| SCHEMBL10115040 | 0.87 | HDAC3 (0.46) | HDAC3HDAC1ALDH1A1HPGDKMT2A | |
| SCHEMBL10133498 | 0.87 | HDAC3 (0.46) | HDAC3HDAC1ALDH1A1HPGDKMT2A | |
| SCHEMBL10133420 | 0.86 | KMT2A (0.39) | HDAC3HDAC1ALDH1A1KMT2AMEN1 | |
| SCHEMBL10115320 | 0.86 | KMT2A (0.39) | HDAC3HDAC1ALDH1A1KMT2AMEN1 | |
| SCHEMBL17090541 | 0.86 | NPY5R (0.42) | ALDH1A1NPY5RHTR1AWDR5 | |
| SCHEMBL13564951 | 0.86 | NPY5R (0.42) | ALDH1A1NPY5RHTR1AWDR5 | |
| SCHEMBL10115213 | 0.85 | HTR1A (0.40) | HDAC3HDAC1ALDH1A1KMT2AMEN1 | |
| SCHEMBL10133750 | 0.85 | HTR1A (0.40) | HDAC3HDAC1ALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8115027-B2 | NPY Y5 antagonist | SHIONOGI & CO., LTD. (JP) | 2012-02-14 | — | — | US | disclosed |
| US-20110039802-A1 | NPY Y5 ANTAGONIST | KAWANISHI YASUYUKI | 2011-02-17 | — | — | US | disclosed |
| US-20100292500-A1 | NPY Y5 ANTAGONIST | KAWANISHI YASUYUKI | 2010-11-18 | — | — | US | disclosed |
| US-7781461-B2 | NPY Y5 antagonist | KAWANISHI YASUYUKI | 2010-08-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100292500-A1 | NPY Y5 ANTAGONIST | NPY5R, NPY1R, NPY2R | HDAC3 489/4885HDAC1 1703/4885ALDH1A1 4599/4885 |
| US-20110039802-A1 | NPY Y5 ANTAGONIST | NPY5R, NPY1R, NPY2R | HDAC3 669/4885HDAC1 2021/4885ALDH1A1 4517/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.