HTR1A

5-hydroxytryptamine receptor 1A · P08908 · HTR1A on Sugi Atlas →

652,783 patent compounds predicted against HTR1A, 407,730 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Sumatriptan (SCHEMBL1482)	1.00	13/20
Pindolol (SCHEMBL5219)	1.00	12/20
Pindolol (SCHEMBL5220)	1.00	12/20
Rizatriptan (SCHEMBL26662)	1.00	12/20
Trazodone (SCHEMBL28167)	1.00	12/20
SCHEMBL8689	0.64	9/20
SCHEMBL29966	0.61	9/20
Buspirone (SCHEMBL16398)	1.00	8/20
Ziprasidone (SCHEMBL28028)	1.00	8/20
Hydrochloric Acid (SCHEMBL2312)	0.96	8/20
Serotonin (SCHEMBL1495)	1.00	7/20
Almotriptan (SCHEMBL1957)	1.00	7/20
SCHEMBL1437	0.98	7/20
Almotriptan (SCHEMBL2166)	0.98	7/20
SCHEMBL21594	0.65	7/20
Promethazine (SCHEMBL4700)	1.00	6/20
Chlorpromazine (SCHEMBL8321)	1.00	6/20
Mianserin (SCHEMBL18020)	1.00	6/20
Prochlorperazine (SCHEMBL18429)	1.00	6/20
Methylpromazine (SCHEMBL18993)	1.00	6/20

Clinical trials — most relevant to HTR1A by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Serotonin Transporter Genetic Variation and Amygdala Responses to Antidepressant Medications in Major Depression	PHASE4	COMPLETED
Sumatriptan as Treatment for Post-traumatic Headache	PHASE2	COMPLETED
Psilocybe Cubensis Mushrooms With or Without Fluoxetine for Refractory Depression	PHASE1/PHASE2	RECRUITING
Serotonin-receptor Agonism in Reward Processing	PHASE2	COMPLETED
Psilocybin With Pimavanserin Compared to Psilocybin Alone for the Treatment of Major Depressive Disorder	PHASE2	RECRUITING
Phase 1b/2a Clinical Trial to Determine the Safety, Tolerability and Efficacy of TZ-161 in Spinal Cord Injury	PHASE1/PHASE2	RECRUITING
Evaluation of [18F]MPPF as a Brain Tracer of Serotonin Receptor 5HT1a	PHASE1	COMPLETED
The Neurobiological Effect of 5-HT2AR Modulation	PHASE1	RECRUITING
Effects of SERT Inhibition on the Subjective Response to Psilocybin in Healthy Subjects	PHASE1	COMPLETED
A Dose-Ranging Study of JNJ-40411813 in Healthy Male Volunteers	PHASE1	COMPLETED
The Study of a Selective 5-ht6 Receptor Antagonist, HEC30654AcOH,in Healthy Subjects	PHASE1	COMPLETED
PET Whole Body Distribution Studies Using [11C]CUMI	nan	COMPLETED
Epigenetic and Neurochemical Correlates of Bipolar Disorder	nan	NOT_YET_RECRUITING
Evaluation of [11C]Cimbi-36 as an Agonist PET Radioligand for Imaging of 5-HT2A Receptors	nan	COMPLETED
Hormonal Causes of Menstrual-Related Mood Disorders	nan	COMPLETED
Examination of Brain Serotonin Receptors in Patients With Mood Disorders	nan	COMPLETED
The Pill Project - Oral Contraceptive and Serotonergic Brain Signaling	nan	UNKNOWN
Trazodone and the Risk of Serious Adverse Events	nan	COMPLETED
The Efficacy of Tianeptine Versus Pregabalin on Acute and Chronic Post Mastectomy Pain After Breast Cancer Surgery.	nan	COMPLETED
The Role of 5-HT2A Receptor in the Perception of Self and Personal Meaning in Healthy Volunteers	nan	COMPLETED
Genetic Variants Associated With Adolescent Suicide Attempts	nan	COMPLETED
Psychobiological Characterization of Depression in Hepatitis C	nan	UNKNOWN
Imaging Serotonin 5HT1A Receptors in Patients With Major Depressive Disorder	nan	WITHDRAWN
Investigating Serotonin Signalling in IBD Patients	nan	RECRUITING
Investigating the Neuropsychological Effects of 5-HT2a Antagonism	nan	RECRUITING
5-HT7 Receptor Implication in Inflammatory Mechanisms in Multiple Sclerosis	nan	COMPLETED
Effects of Lurasidone on Left Ventricle Systolic Functions	nan	NOT_YET_RECRUITING
Development of A Technique to Predict Antidepressant Responsiveness in Depressive Patients	nan	UNKNOWN
Pre-Treatment Positron Emission Topography Scanning for Increasing Success in Antidepressant Treatment	nan	COMPLETED
TSK (Tryptophan - Serotonin - Kynurenine) Biomarkers Assessment in Stroke	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a HTR1A binder may also engage these)

Protein	Name	Similarity
Q9N297	—	1.000	Q9N297 →
Q6XXX9	—	1.000	Q6XXX9 →
Q9N298	—	1.000	Q9N298 →
Q6XXY0	—	1.000	Q6XXY0 →
Q9N296	—	1.000	Q9N296 →
Q0EAB6	—	1.000	Q0EAB6 →
P19327	—	1.000	P19327 →
Q64264	—	1.000	Q64264 →
O42385	—	1.000	O42385 →
O42384	—	1.000	O42384 →
Q25322	—	1.000	Q25322 →
Q25321	—	0.999	Q25321 →
Q91081	—	0.998	Q91081 →
P79250	—	0.996	P79250 →
HTR1B	5-hydroxytryptamine receptor 1B	0.996	landscape →
P35404	—	0.996	P35404 →
P79748	—	0.995	P79748 →
P18901	—	0.995	P18901 →
Q98998	—	0.995	Q98998 →
Q6XXX8	—	0.995	Q6XXX8 →
DRD2	D(2) dopamine receptor	0.995	landscape →
O70528	—	0.994	O70528 →
DRD1	D(1A) dopamine receptor	0.994	landscape →
Q9N2B7	—	0.994	Q9N2B7 →
P28564	—	0.993	P28564 →
P60026	—	0.993	P60026 →
Q588Y6	—	0.993	Q588Y6 →
P97288	—	0.993	P97288 →
P56496	—	0.993	P56496 →
O08892	—	0.993	O08892 →