Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 18/20 | 0.54 |
| ▸ | AXL | P30530 | 6/20 | 0.54 |
| ▸ | KDR | P35968 | 2/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.36 |
| ▸ | MERTK | Q12866 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10133801 | 0.89 | MET (0.46) | METAXLKDRAURKBATM | |
| SCHEMBL18040371 | 0.88 | MET (0.47) | METAXLKDR | |
| SCHEMBL14949029 | 0.88 | MET (0.43) | METAXLKDRAURKB | |
| SCHEMBL10133775 | 0.86 | MET (0.50) | METAXLKDRAURKBTYRO3 | |
| SCHEMBL10134550 | 0.85 | MET (0.67) | METAXLKDR | |
| SCHEMBL371039 | 0.81 | MET (0.51) | METAXLKDR | |
| SCHEMBL368546 | 0.80 | MET (0.65) | METAXLKDR | |
| SCHEMBL18040358 | 0.77 | MET (0.48) | METAXLKDR | |
| SCHEMBL14949032 | 0.77 | MET (0.41) | METAXLKDRAURKBMERTK | |
| SCHEMBL18040360 | 0.74 | MET (0.54) | METAXLKDRAURKBTYRO3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593462-B1 | NOVEL FUSED HETEROCYCLIC DERIVATIVES USEFUL AS C-MET TYROSINE KINASE INHIBITORS | BETTA PHARMACEUTICALS CO LTD (CN) | 2016-09-07 | — | — | EP | disclosed |
| WO-2012006960-A1 | NOVEL FUSED HETEROCYCLIC DERIVATIVES USEFUL AS c-MET TYROSINE KINASE INHIBITORS | ZHEJIANG BETA PHARMA INC. (CN) | 2012-01-19 | — | — | WO | disclosed |