Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 9/20 | 0.65 |
| ▸ | ABL1 | P00519 | 8/20 | 0.60 |
| ▸ | BCR | P11274 | 8/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1013045 | 0.92 | TRPV1 (0.72) | TRPV1ABL1BCRFAAH | |
| SCHEMBL1011253 | 0.83 | TRPV1 (0.83) | TRPV1ABL1BCRMEN1USP2 | |
| SCHEMBL1013803 | 0.82 | TRPV1 (0.75) | TRPV1ABL1BCRTP53FAAH | |
| SCHEMBL1016411 | 0.81 | ABL1 (0.68) | TRPV1ABL1BCRMEN1USP2 | |
| SCHEMBL1012547 | 0.81 | TRPV1 (0.72) | TRPV1ABL1BCRFAAH | |
| SCHEMBL1016320 | 0.81 | ABL1 (0.76) | TRPV1ABL1BCRMEN1USP2 | |
| SCHEMBL1017086 | 0.79 | ABL1 (0.65) | TRPV1ABL1BCRMEN1USP2 | |
| SCHEMBL13868105 | 0.79 | TRPV1 (1.00) | TRPV1ABL1BCRFAAH | |
| SCHEMBL1012994 | 0.79 | TRPV1 (0.72) | TRPV1ABL1BCRTP53FAAH | |
| SCHEMBL1014056 | 0.79 | TRPV1 (0.72) | TRPV1ABL1BCRMEN1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1542692-B1 | AMINOPYRIMIDINE DERIVATIVES FOR USE AS VANILLOID RECEPTOR LIGANDS FOR THE TREATMENT OF PAIN | AMGEN INC (US) | 2011-01-05 | — | — | EP | claimed |