Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 18/20 | 0.87 |
| ▸ | KDR | P35968 | 4/20 | 0.80 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.80 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.80 |
| ▸ | RAF1 | P04049 | 10/20 | 0.79 |
| ▸ | EGFR | P00533 | 1/20 | 0.70 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1779737 | 0.93 | BRAF (1.00) | BRAFKDRMAPK14TNNI3KRAF1 | |
| SCHEMBL1780469 | 0.92 | BRAF (0.84) | BRAFKDRRAF1 | |
| SCHEMBL1012696 | 0.89 | BRAF (1.00) | BRAFKDRMAPK14TNNI3KRAF1 | |
| SCHEMBL1013152 | 0.89 | BRAF (1.00) | BRAFKDRMAPK14TNNI3KRAF1 | |
| SCHEMBL1015749 | 0.88 | BRAF (1.00) | BRAFKDRMAPK14TNNI3KRAF1 | |
| SCHEMBL1012329 | 0.87 | BRAF (1.00) | BRAFKDRRAF1EGFR | |
| SCHEMBL1012844 | 0.87 | BRAF (1.00) | BRAFKDRMAPK14TNNI3KRAF1 | |
| SCHEMBL1013893 | 0.87 | BRAF (0.70) | BRAFKDRMAPK14TNNI3KRAF1 | |
| SCHEMBL1011531 | 0.86 | BRAF (1.00) | BRAFKDRMAPK14TNNI3KRAF1 | |
| SCHEMBL1013263 | 0.85 | BRAF (1.00) | BRAFKDRMAPK14TNNI3KRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3147281-A1 | QUINAZOLINE DERIVATIVES AS RAF KINASE MODULATORS AND METHODS OF USE THEREOF | Ambit Biosciences Corporation (US) | 2017-03-29 | — | — | EP | claimed |
| JP-2011529021-A | — | — | 2011-12-01 | — | — | JP | claimed |
| EP-2268623-A1 | QUINAZOLINE DERIVATIVES AS RAF KINASE MODULATORS AND METHODS OF USE THEREOF | Ambit Biosciences Corporation (US) | 2011-01-05 | — | — | EP | claimed |
| WO-2009117080-A1 | QUINAZOLINE DERIVATIVES AS RAF KINASE MODULATORS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATON (US) | 2009-09-24 | — | — | WO | claimed |
| EP-3147281-A1 | QUINAZOLINE DERIVATIVES AS RAF KINASE MODULATORS AND METHODS OF USE THEREOF | Ambit Biosciences Corporation (US) | 2017-03-29 | — | — | EP | disclosed |