Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 17/20 | 0.70 |
| ▸ | RAF1 | P04049 | 9/20 | 0.65 |
| ▸ | KDR | P35968 | 5/20 | 0.65 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.65 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.65 |
| ▸ | EGFR | P00533 | 2/20 | 0.57 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1013892 | 0.87 | BRAF (0.87) | BRAFRAF1KDRMAPK14TNNI3K | |
| SCHEMBL1779737 | 0.83 | BRAF (1.00) | BRAFRAF1KDRMAPK14TNNI3K | |
| SCHEMBL1013152 | 0.79 | BRAF (1.00) | BRAFRAF1KDRMAPK14TNNI3K | |
| SCHEMBL1780469 | 0.79 | BRAF (0.84) | BRAFRAF1KDR | |
| SCHEMBL1015749 | 0.79 | BRAF (1.00) | BRAFRAF1KDRMAPK14TNNI3K | |
| SCHEMBL28759820 | 0.79 | BRAF (0.82) | BRAFRAF1KDRMAPK14TNNI3K | |
| SCHEMBL29723231 | 0.79 | BRAF (0.82) | BRAFRAF1KDRMAPK14TNNI3K | |
| SCHEMBL1012844 | 0.78 | BRAF (1.00) | BRAFRAF1KDRMAPK14TNNI3K | |
| SCHEMBL1012696 | 0.78 | BRAF (1.00) | BRAFRAF1KDRMAPK14TNNI3K | |
| SCHEMBL28979429 | 0.77 | BRAF (0.79) | BRAFRAF1KDRMAPK14TNNI3K |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2011529021-A | — | — | 2011-12-01 | — | — | JP | claimed |
| EP-2268623-A1 | QUINAZOLINE DERIVATIVES AS RAF KINASE MODULATORS AND METHODS OF USE THEREOF | Ambit Biosciences Corporation (US) | 2011-01-05 | — | — | EP | claimed |
| WO-2009117080-A1 | QUINAZOLINE DERIVATIVES AS RAF KINASE MODULATORS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATON (US) | 2009-09-24 | — | — | WO | claimed |