SCHEMBL10138946

SCHEMBL10138946

COC(=O)[C@@H]1CC(F)(F)CN1C(C)=O

nearest known ligand 0.46

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
MMP2 P08253 14/20 0.46
ANPEP P15144 6/20 0.46
PEPD P12955 1/20 0.39
POLB P06746 1/20 0.37
DPP4 P27487 1/20 0.36
DPP8 Q6V1X1 1/20 0.36
DPP7 Q9UHL4 1/20 0.36
EPHX2 P34913 1/20 0.33
CNR2 P34972 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3012517 0.86 PEPD (0.39) MMP2ANPEPPEPDPOLBDPP4
SCHEMBL21199412 0.82 PEPD (0.37) MMP2ANPEPPEPDPOLBDPP4
SCHEMBL16300657 0.82 DPP4 (0.34) DPP4DPP8DPP7EPHX2CNR2
SCHEMBL32683359 0.81 DPP4 (0.41) MMP2ANPEPPEPDPOLBDPP4
SCHEMBL19083941 0.80 ATM (0.43) POLBDPP4DPP8DPP7CNR2
SCHEMBL2207075 0.80 PTPN1 (0.40) PEPDPOLBDPP4DPP8DPP7
SCHEMBL1701540 0.80 PTPN1 (0.40) PEPDPOLBDPP4DPP8DPP7
SCHEMBL706243 0.80 PTPN1 (0.40) PEPDPOLBDPP4DPP8DPP7
SCHEMBL29142179 0.79 POLB (0.36) MMP2ANPEPPEPDPOLBDPP4
SCHEMBL29142178 0.79 POLB (0.36) MMP2ANPEPPEPDPOLBDPP4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260069602-A1 COMPOUNDS, COMPOSITIONS, AND METHODS ACONCAGUA BIO INC (US) 2026-03-12 US disclosed
US-RE43298-E1 Peptides as NS3-serine protease inhibitors of hepatitis C virus SCHERING CORPORATION (US) 2012-04-03 US disclosed
US-20110117057-A1 NOVEL PEPTIDES AS NS3-SERINE PROTEASE INHIBITORS OF HEPATITIS C VIRUS SCHERING CORPORATION (US) 2011-05-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110117057-A1 NOVEL PEPTIDES AS NS3-SERINE PROTEASE INHIBITORS OF HEPATITIS C VIRUS HPN, TMPRSS15, VIP MMP2 425/4885ANPEP 22/4885PEPD 12/4885
US-20260069602-A1 COMPOUNDS, COMPOSITIONS, AND METHODS SCTR, SSTR1, NPY1R MMP2 4076/4885ANPEP 1026/4885PEPD 3115/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.