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Sugi Predict / Targets / TMPRSS15

TMPRSS15

Enteropeptidase · P98073 · TMPRSS15 on Sugi Atlas →

10,650 patent compounds predicted against TMPRSS15, 4,538 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
Butane Butane (SCHEMBL3243913) 0.54 20/20
Butane Butane (SCHEMBL3237834) 0.54 19/20
SCHEMBL4105609 SCHEMBL4105609 0.46 17/20
Butane Butane (SCHEMBL3234863) 0.53 16/20
SCHEMBL3237873 SCHEMBL3237873 0.64 15/20
SCHEMBL3237626 SCHEMBL3237626 0.63 15/20
SCHEMBL3237777 SCHEMBL3237777 0.60 15/20
SCHEMBL3240172 SCHEMBL3240172 0.59 15/20
Butane Butane (SCHEMBL3231173) 0.59 15/20
SCHEMBL3243888 SCHEMBL3243888 0.59 15/20
SCHEMBL3239670 SCHEMBL3239670 0.57 15/20
Butane Butane (SCHEMBL3238160) 0.56 15/20
Butane Butane (SCHEMBL3238792) 0.56 15/20
SCHEMBL3244672 SCHEMBL3244672 0.56 15/20
SCHEMBL3239747 SCHEMBL3239747 0.56 15/20
SCHEMBL3238641 SCHEMBL3238641 0.55 15/20
SCHEMBL3238554 SCHEMBL3238554 0.54 15/20
SCHEMBL3241819 SCHEMBL3241819 0.54 15/20
SCHEMBL3236111 SCHEMBL3236111 0.52 15/20
SCHEMBL3239647 SCHEMBL3239647 0.49 15/20

Clinical trials — most relevant to TMPRSS15 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Assessment the Activity Value of Isotretinoin (13- Cis-Retinoic Acid ) in the Treatment of COVID-19 ( Isotretinoin in Treatment of COVID-19) (Randomized) PHASE3UNKNOWN
Efficacy and Safety of Favipiravir and Ribavirin Formulation for Treatment of COVID-19 PHASE2/PHASE3UNKNOWN
Combination Therapy With Isotretinoin and Tamoxifen Expected to Provide Complete Protection Against Severe Acute Respiratory Syndrome Coronavirus PHASE2UNKNOWN
Androgen Deprivation Therapy and Vorinostat Followed by Radical Prostatectomy in Treating Patients With Localized Prostate Cancer PHASE2COMPLETED
An Extension Study of HGT-HIT-045 Evaluating Long-Term Safety and Clinical Outcomes of Idursulfase-IT in Conjunction With Elaprase in Pediatric Participants With Hunter Syndrome and Cognitive Impairment PHASE1/PHASE2COMPLETED
NestaCell® Mesenchymal Stem Cell to Treat Patients With Severe COVID-19 Pneumonia PHASE2COMPLETED
Sputum Matrix Metalloproteinases (MMP) mRNA and Montelukast PHASE2COMPLETED
Nebulised BromAc in Healthy Volunteers PHASE1COMPLETED
Use of Mesenchymal Stem Cells in Acute Respiratory Distress Syndrome Caused by COVID-19 EARLY_PHASE1UNKNOWN
CoVID-19 Plasma in Treatment of COVID-19 Patients EARLY_PHASE1COMPLETED
Osteopathic Manipulative Therapy Effects on Post-Acute Sequelae of COVID-19 (PASC) or Long COVID nanRECRUITING
Genetic Determinism of Epithelial Barrier Defects in Irritable Bowel Syndrome nanWITHDRAWN
ACE2 Gender Differences in Stroke With COVID-19 nanCOMPLETED
ERG Protein Expression in Prostatic Adenocarcinoma and Its Clinicopathological Features nanUNKNOWN
Esophageal String Test in Eosinophilic Esophagitis nanACTIVE_NOT_RECRUITING
Study of Tissue, Blood, and Urine Samples From Patients With Advanced Prostate Cancer nanUNKNOWN
Impact of the Genetic Polymorphism on COVID-19 in Egypt nanUNKNOWN
Assessing the Impacts of a UESAD on Laryngeal Symptoms and Salivary Pepsin nanCOMPLETED
Periodontal Health in Post COVID-19 Patients nanUNKNOWN
PAR Family Polymorphisms and Placental Invasion Disorders nanUNKNOWN
Influence of Genetic Polymorphisms on Ventricular Structure and Function in Patients With Single Ventricle Anatomy nanCOMPLETED
Association Between Periodontitis and Coronavirus Disease (COVID-19) nanCOMPLETED
MIcrovascular Dysfunction in CRitically Ill cOVID-19 Patients nanUNKNOWN
Acute Pancreatitis Targets (APT) Study nanCOMPLETED
COVID-19 Blood Pressure Endothelium Interaction Study (OBELIX) nanCOMPLETED
Integrated Proteomic HPLC-ESI-MS Analysis of Salivary Peptides of Preterm Newborns: a Pilot Study nanCOMPLETED
Mucin Glycosylating Enzymes in Head and Neck Cancers nanUNKNOWN
MMP Polymorphisms and Acute Coronary Syndromes nanCOMPLETED
Protein Digestion and Amino Acid Absorption in the Aging Gastrointestinal Tract nanCOMPLETED
Proteases in Patients With Prostate Cancer That Has Spread to the Bone nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a TMPRSS15 binder may also engage these)

ProteinNameSimilarity
P98072 — 1.000 P98072 →
P98074 — 1.000 P98074 →
P97435 — 1.000 P97435 →
Q7RTY8 — 0.995 Q7RTY8 →
P79953 — 0.994 P79953 →
Q90WD8 — 0.994 Q90WD8 →
Q66TN7 — 0.994 Q66TN7 →
P86091 — 0.993 P86091 →
Q8BIK6 — 0.993 Q8BIK6 →
Q20176 — 0.993 Q20176 →
P56677 — 0.992 P56677 →
ST14 Suppressor of tumorigenicity 14 protein 0.992 landscape →
P29598 — 0.992 P29598 →
P26262 — 0.991 P26262 →
A0A182C2Z2 — 0.991 A0A182C2Z2 →
O60494 — 0.991 O60494 →
Q14C59 — 0.991 Q14C59 →
Q5R544 — 0.990 Q5R544 →
O57382 — 0.990 O57382 →
Q4R577 — 0.990 Q4R577 →
Q7RTZ1 — 0.990 Q7RTZ1 →
Q86T26 — 0.990 Q86T26 →
P11214 — 0.990 P11214 →
TMPRSS4 Transmembrane protease serine 4 0.990 landscape →
Q58L93 — 0.989 Q58L93 →
F11 Coagulation factor XI 0.989 landscape →
Q08048 — 0.989 Q08048 →
Q1L659 — 0.989 Q1L659 →
Q9WUW3 — 0.989 Q9WUW3 →
Q2KJ63 — 0.989 Q2KJ63 →