Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.51 |
| ▸ | FLT3 | P36888 | 2/20 | 0.51 |
| ▸ | GSK3B | P49841 | 2/20 | 0.51 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.51 |
| ▸ | PIM1 | P11309 | 1/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.51 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.49 |
| ▸ | FYN | P06241 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.46 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | MET | P08581 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | PRKACA | P17612 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31195434 | 1.00 | HTT (0.52) | HTTCLK4NTRK1FLT3GSK3B | |
| SCHEMBL12240967 | 0.84 | CLK4 (0.62) | HTTCLK4NTRK1FLT3GSK3B | |
| SCHEMBL15187776 | 0.84 | CLK4 (0.62) | HTTCLK4NTRK1FLT3GSK3B | |
| SCHEMBL3251777 | 0.84 | CLK4 (0.46) | HTTCLK4NTRK1FLT3GSK3B | |
| SCHEMBL23137995 | 0.84 | CLK4 (0.46) | HTTCLK4NTRK1FLT3GSK3B | |
| SCHEMBL28893845 | 0.84 | CA12 (0.56) | CLK4NTRK1FLT3GSK3BDAPK3 | |
| SCHEMBL16330399 | 0.83 | CLK4 (0.45) | HTTCLK4NTRK1FLT3GSK3B | |
| SCHEMBL32666530 | 0.81 | CA12 (0.54) | CLK4NTRK1FLT3GSK3BDAPK3 | |
| SCHEMBL23137994 | 0.81 | CLK4 (0.44) | HTTCLK4NTRK1FLT3GSK3B | |
| SCHEMBL9214155 | 0.79 | PARP10 (0.62) | HTTPARP1PARP10GRM5PARP11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8148363-B2 | Heterocyclic compounds as factor IXA inhibitors | SCHERING CORPORATION (US) | 2012-04-03 | — | — | US | disclosed |
| US-20110065682-A1 | HETEROCYCLIC COMPOUNDS AS FACTOR IXA INHIBITORS | MERCK SHARP & DOHME LLC | 2011-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110065682-A1 | HETEROCYCLIC COMPOUNDS AS FACTOR IXA INHIBITORS | F9, F12, F8 | HTT 3243/4885CLK4 4548/4885NTRK1 4506/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.