Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 2/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.37 |
| ▸ | MRGPRX4 | Q96LA9 | 4/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1014598 | 0.90 | ROCK1 (0.53) | ROCK1FFAR4S1PR5PTGER1MRGPRX4 | |
| SCHEMBL1013518 | 0.88 | S1PR5 (0.38) | ROCK1S1PR5PTGER1MRGPRX4RAB9A | |
| SCHEMBL13748568 | 0.84 | HTR1A (0.45) | ROCK1FFAR4S1PR5PTGER1CYP2C9 | |
| SCHEMBL12532035 | 0.83 | S1PR5 (0.35) | ROCK1FFAR4S1PR5PTGER1MRGPRX4 | |
| SCHEMBL1727591 | 0.83 | MAOB (0.36) | FFAR4S1PR5 | |
| SCHEMBL1728482 | 0.83 | S1PR5 (0.39) | ROCK1FFAR4S1PR5PTGER1MRGPRX4 | |
| SCHEMBL1727695 | 0.80 | S1PR5 (0.38) | FFAR4S1PR5PTGER1MRGPRX4RAB9A | |
| SCHEMBL2003613 | 0.80 | MAPK14 (0.44) | S1PR5PTGER1MRGPRX4 | |
| SCHEMBL1016697 | 0.79 | S1PR5 (0.40) | ROCK1S1PR5PTGER1MRGPRX4KDM1A | |
| SCHEMBL1014339 | 0.78 | FFAR4 (0.56) | ROCK1FFAR4MRGPRX4KDM1ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2271617-A1 | SUBSTITUTED 4-HYDROXY-N- (4-HYDROXYPHENYL) INDOLES AS ESTROGENIC AGENTS | Glaxo Group Limited (GB) | 2011-01-12 | — | — | EP | disclosed |
| WO-2009103710-A1 | SUBSTITUTED 4-HYDROXY-N- (4-HYDROXYPHENYL) INDOLES AS ESTROGENIC AGENTS | GLAXO GROUP LIMITED (GB) | 2009-08-27 | — | — | WO | disclosed |