Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | STS | P08842 | 4/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 3/20 | 0.36 |
| ▸ | PARP15 | Q460N3 | 2/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13743683 | 1.00 | NFE2L2 (0.47) | NFE2L2MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL1147939 | 0.88 | SMN1; SMN2 (0.43) | MAPK14MAPK13MAPK12MAPK11ALDH1A1 | |
| SCHEMBL490765 | 0.88 | SMN1; SMN2 (0.43) | MAPK14MAPK13MAPK12MAPK11ALDH1A1 | |
| SCHEMBL5324639 | 0.84 | MAPT (0.47) | TDP1LTA4HPTGS1PTGS2HRH3 | |
| SCHEMBL5324642 | 0.84 | MAPT (0.47) | TDP1LTA4HPTGS1PTGS2HRH3 | |
| SCHEMBL12395416 | 0.83 | TDP1 (0.43) | NFE2L2MAPK14TDP1CYP19A1ALDH1A1 | |
| SCHEMBL14196755 | 0.82 | MEN1 (0.51) | MAPK14MAPK13MAPK12MAPK11TDP1 | |
| SCHEMBL5325622 | 0.81 | NFE2L2 (0.44) | NFE2L2TDP1CYP19A1ALDH1A1 | |
| SCHEMBL5325625 | 0.81 | NFE2L2 (0.44) | NFE2L2TDP1CYP19A1ALDH1A1 | |
| SCHEMBL191993 | 0.77 | HDAC1 (0.48) | LTA4HALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079743-B1 | PTERIDINE DERIVATIVES AS POLO-LIKE KINASE INHIBITORS USEFUL IN THE TREATMENT OF CANCER | CHROMA THERAPEUTICS LTD (GB) | 2012-01-25 | — | — | EP | disclosed |
| WO-2008050096-A1 | PTERIDINE DERIVATIVES AS POLO-LIKE KINASE INHIBITORS USEFUL IN THE TREATMENT OF CANCER | CHROMA THERAPEUTICS LTD. (GB) | 2008-05-02 | — | — | WO | disclosed |