NFE2L2 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL92951	0.60	16/20
SCHEMBL81704	0.58	16/20
SCHEMBL22692	0.65	10/20
SCHEMBL22693	0.65	10/20
SCHEMBL31350	0.65	10/20
SCHEMBL74725	0.50	10/20
SCHEMBL74726	0.50	10/20
SCHEMBL74727	0.50	10/20
SCHEMBL67448	0.45	10/20
SCHEMBL103244	0.59	9/20
SCHEMBL74380	0.50	9/20
SCHEMBL57085	0.58	8/20
SCHEMBL18152	0.53	8/20
SCHEMBL21124	0.64	7/20
SCHEMBL74265	0.56	7/20
SCHEMBL74266	0.56	7/20
SCHEMBL105258	0.54	7/20
SCHEMBL73226	0.50	7/20
SCHEMBL73227	0.50	7/20
SCHEMBL39163	0.43	7/20

Clinical trials — most relevant to NFE2L2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Motor Function Efficacy of Pharmacological Treatments Targeting Energy Metabolism, in Parkinson's Patients	PHASE4	UNKNOWN
Effect of Melatonin in Patients With Diabetic Peripheral Neuropathy	PHASE2	RECRUITING
Testing the Combination of MLN4924 (Pevonedistat), Carboplatin, and Paclitaxel in Patients With Advanced Non-small Cell Lung Cancer (NSCLC) Who Have Previously Been Treated With Immunotherapy	PHASE2	ACTIVE_NOT_RECRUITING
Glucosamine Sulphate Versus Ginger in Non-Surgical Periodontal Therapy	PHASE2	COMPLETED
Broccoli Sprout Extracts Trial to See if NRF2 is Enhanced by Sulforaphane Treatment in Patients With COPD	PHASE2	COMPLETED
A Study of Bezafibrate in Mitochondrial Myopathy	PHASE2	COMPLETED
Effect of Gamma Tocopherol Enriched Supplementation on Response to Inhaled O3 Exposure	PHASE2	COMPLETED
A Study to Learn About the Effects and Safety of RTA 408 (Omaveloxolone) in People Aged 16 to 40 With Friedreich's Ataxia	PHASE2	COMPLETED
Study of the Effects of Iron on Lung Blood Pressure at High Altitude	PHASE2	WITHDRAWN
Melatonin in Healthy Volunteers	PHASE1	COMPLETED
Impact of Nrf2 Activation on Macrovascular, Microvascular & Leg Function & Walking Capacity in Peripheral Artery Disease	EARLY_PHASE1	RECRUITING
Characterization of the Nrf2 Response in Patients With Autosomal Dominant Polycystic Kidney Disease (ADPKD)	nan	RECRUITING
Evaluation of the Predictive Effect of Inflammatory Markers in MI Patients	nan	UNKNOWN
Treatment Strategy to Enhance Nrf2 Signaling in Older Adults	nan	COMPLETED
ADAPT: Efficacy of a Dietary Supplement During and After Exercise	nan	COMPLETED
Tecfidera Diffusion Tensor Imaging	nan	COMPLETED
Cell Signaling and Resistance to Oxidative Stress: Effects of Aging and Exercise	nan	COMPLETED
Effects of Gallotannins on the Gut Microbiome and How it Affects Inflammatory Markers Among Obese Individuals.	nan	ACTIVE_NOT_RECRUITING
INTERVAL - Intense Exercise Trial for Men With Metastatic Castrate-Resistant Prostate Cancer	nan	UNKNOWN
Human Study of Hydroxytyrosol on Phase II Enzymes in Healthy Subjects	nan	COMPLETED
Mild Intermittent Hypoxia and Its Multipronged Effect on Sleep Apnea	nan	RECRUITING
Cerebral and Anti-inflammatory Response Through Exercise - Mechanisms In Depressive Disorders	nan	RECRUITING
Effects of Curcumin on Markers of Cardiovascular Risk in Patients With CAD	nan	WITHDRAWN
Effect of Protein on Endoplasmic Reticulum Stress	nan	NOT_YET_RECRUITING
Targeting Oxidative Stress to Prevent Vascular and Skeletal Muscle Dysfunction During Disuse	nan	ACTIVE_NOT_RECRUITING
Prognostic Value of Combined Approach Based on KEAP1/NFE2L2 Mutations and Pre-therapeutic FDG-PET/CT Radiomic Analysis in Advanced Non-small-cell Lung Cancer PDL1 ≥ 50% Treated With Pembrolizumab (PEMBROMIC)	nan	UNKNOWN
Pathogenic Insights and Search for Biomarkers in RFC1-ataxia/CANVAS	nan	RECRUITING
Pituitary Derived-Intermedin is an Estrogen-Modulated Factor for Reducing Blood Pressure	nan	UNKNOWN
Effect of Total Knee Arthroplasty on Sarcopenia in Patients With Osteoarthritis in the Knee	nan	COMPLETED
Skeletal Muscle Mitochondrial Abnormalities and the Metabolic Syndrome in PAH	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a NFE2L2 binder may also engage these)

Protein	Name	Similarity
Q5NUA6	—	1.000	Q5NUA6 →
O54968	—	1.000	O54968 →
Q60795	—	1.000	Q60795 →
Q8R5I7	—	0.995	Q8R5I7 →
Q8CDG5	—	0.993	Q8CDG5 →
F1QDF8	—	0.990	F1QDF8 →
Q3ZCH6	—	0.990	Q3ZCH6 →
Q62661	—	0.990	Q62661 →
D4AEC2	—	0.990	D4AEC2 →
Q8QGQ8	—	0.990	Q8QGQ8 →
Q9NQW6	—	0.990	Q9NQW6 →
Q9FY74	—	0.989	Q9FY74 →
Q8IUR6	—	0.989	Q8IUR6 →
Q8IZQ8	—	0.989	Q8IZQ8 →
Q68EL6	—	0.989	Q68EL6 →
Q28GJ0	—	0.989	Q28GJ0 →
Q90Z72	—	0.989	Q90Z72 →
Q61985	—	0.989	Q61985 →
P56931	—	0.989	P56931 →
Q5M7N6	—	0.989	Q5M7N6 →
P46200	—	0.989	P46200 →
Q6IMZ0	—	0.988	Q6IMZ0 →
Q3KQW7	—	0.988	Q3KQW7 →
Q922B9	—	0.988	Q922B9 →
Q16649	—	0.988	Q16649 →
P10157	—	0.988	P10157 →
Q5FW38	—	0.988	Q5FW38 →
P06537	—	0.988	P06537 →
Q32NH9	—	0.988	Q32NH9 →
P28290	—	0.988	P28290 →