Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.48 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | ENPP3 | O14638 | 3/20 | 0.46 |
| ▸ | ENPP1 | P22413 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3344765 | 0.83 | POLB (0.46) | POLBMAPTMEN1KMT2AGAA | |
| SCHEMBL17730022 | 0.82 | KMT2A (0.56) | MAPTMEN1KMT2AGAAGFER | |
| SCHEMBL3332482 | 0.82 | POLB (0.59) | POLBMAPTMEN1KMT2AGAA | |
| SCHEMBL3332840 | 0.80 | ABL1 (0.47) | POLBMAPTABL1LMNARAB9A | |
| SCHEMBL3327606 | 0.79 | ABL1 (0.45) | POLBMAPTMEN1KMT2AABL1 | |
| SCHEMBL12058718 | 0.78 | POLB (0.60) | POLBABL1MTNR1AMTNR1BALDH1A1 | |
| SCHEMBL28212694 | 0.77 | MTNR1A (0.72) | POLBMAPTMEN1KMT2AGAA | |
| SCHEMBL3339751 | 0.76 | ABL1 (0.47) | POLBABL1HTT | |
| SCHEMBL3333489 | 0.76 | KDR (0.49) | POLBMAPTMEN1KMT2AABL1 | |
| SCHEMBL3347350 | 0.75 | HCRTR2 (0.52) | POLBABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2404896-A1 | CYCLOHEXANE DERIVATIVE HAVING NPY Y5 RECEPTOR ANTAGONISM | Shionogi&Co., Ltd. (JP) | 2012-01-11 | — | — | EP | disclosed |