MTNR1A — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Ramelteon (SCHEMBL29237)	1.00	20/20
SCHEMBL124323	0.67	20/20
SCHEMBL126737	0.67	20/20
SCHEMBL124849	0.65	20/20
SCHEMBL126410	0.65	20/20
SCHEMBL125427	0.52	20/20
SCHEMBL124618	0.51	20/20
SCHEMBL123197	1.00	19/20
SCHEMBL123962	1.00	19/20
SCHEMBL124885	1.00	19/20
SCHEMBL125264	1.00	19/20
SCHEMBL125268	1.00	19/20
SCHEMBL126690	1.00	19/20
SCHEMBL126994	1.00	19/20
SCHEMBL135600	1.00	19/20
SCHEMBL135601	1.00	19/20
SCHEMBL127176	0.69	19/20
SCHEMBL125365	0.68	19/20
SCHEMBL124106	0.67	19/20
SCHEMBL125422	0.58	19/20

Clinical trials — most relevant to MTNR1A by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Delirium Reduction With Ramelteon	PHASE4	RECRUITING
Effect of Melatonin on Seizure Outcome, Neuronal Damage and Quality of Life in Patients With Generalized Epilepsy	PHASE4	COMPLETED
Efficacy of Ramelteon on Insomnia Symptoms Associated With Jet Lag in Healthy Adult Volunteers	PHASE4	COMPLETED
A Study on the Efficacy of Agomelatine Combined With Antipsychotics to Treat Negative Symptoms in Schizophrenia	PHASE4	UNKNOWN
Safety and Efficacy Study of Ramelteon in Subjects With Chronic Insomnia	PHASE3	COMPLETED
Melatonin and Glucose Tolerance Among Individuals With a Variant of the MTNR1B Gene	PHASE3	COMPLETED
PLAY GAME: Post-concussion Syndrome in Youth - Assessing the GABAergic Effects of Melatonin	PHASE2/PHASE3	UNKNOWN
Safety and Efficacy of Ramelteon in Elderly Subjects With Chronic Insomnia	PHASE3	COMPLETED
Antenatal Melatonin Supplementation for Neuroprotection in Fetal Growth Restriction	PHASE3	RECRUITING
Efficacy and Safety of Ramelteon Combined With Gabapentin in Treating Patients With Insomnia	PHASE2	COMPLETED
Efficacy and Safety of Ramelteon in Subjects With Mild to Moderate Alzheimer's Disease	PHASE2	COMPLETED
Melatonin Agonist on Hospitalized Patients With Confirmed or Suspected COVID-19	PHASE2	UNKNOWN
Acute Metabolic Effects of Melatonin Treatment	PHASE1/PHASE2	COMPLETED
Safety and Efficacy of Ramelteon in Healthy Subjects	PHASE2	COMPLETED
Metabolic Effects of Melatonin Treatment	PHASE1	COMPLETED
Melatonin Osteoporosis Prevention Study	PHASE1	COMPLETED
MTNR1B SNP*Food Timing Interaction on Glucose Control	nan	COMPLETED
Glucose Tolerance, Meal Timing and MTNR1B	nan	COMPLETED
Shift Work, Heredity, Insulin, and Food Timing Study	nan	COMPLETED
Interaction of Melatonin and MTNR1B Genotype on Glucose Control - Study 1	nan	COMPLETED
Meal Timing, Genetics and Weight Loss	nan	RECRUITING
Melatonin Levels and the Relation to Obesity and the Metabolic Syndrome in Children and Adolescents	nan	COMPLETED
Efficacy of the Administration of Melatonin 5mg in the Prevention of Delirium in Older Adults Hospitalized in the Emergency Department	nan	UNKNOWN
Effect of Preoperative Melatonin on Quality of Recovery After Elective Laparoscopic Cholecystectomy	nan	NOT_YET_RECRUITING
Melatonin Receptor Agonist and Peripheral Biological Markers	nan	COMPLETED
Melatonin Impact on the Outcomes of Myocardial Ischemia/Reperfusion Injury During Coronary Artery Bypass Grafting Surgery	nan	UNKNOWN
Interaction of MTNR1B Genotype and Type of Breakfast (Protein-enriched v Carbohydrate-rich) on Postprandial Glucose Response.	nan	COMPLETED
Influence of Caffeine Consumption on the Human Circadian System	nan	COMPLETED
Melatonin in Pregnancy	nan	COMPLETED
Susceptibility to Infectious Diseases in obEsity: an endocRine trAnslational socioLogic Evaluation, SIDERALE	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a MTNR1A binder may also engage these)

Protein	Name	Similarity
P51046	—	1.000	P51046 →
P49285	—	1.000	P49285 →
P49288	—	1.000	P49288 →
P49217	—	1.000	P49217 →
Q61184	—	0.998	Q61184 →
P51049	—	0.997	P51049 →
P48040	—	0.997	P48040 →
P51050	—	0.997	P51050 →
P49287	—	0.997	P49287 →
Q8CIQ6	—	0.996	Q8CIQ6 →
MTNR1B	Melatonin receptor type 1B	0.993	landscape →
O70528	—	0.993	O70528 →
HTR4	5-hydroxytryptamine receptor 4	0.991	landscape →
P49219	—	0.991	P49219 →
P97288	—	0.991	P97288 →
O02769	—	0.991	O02769 →
Q90456	—	0.990	Q90456 →
Q62758	—	0.988	Q62758 →
Q2KI97	—	0.988	Q2KI97 →
GPR84	G-protein coupled receptor 84	0.987	landscape →
P30966	—	0.986	P30966 →
Q91081	—	0.985	Q91081 →
O42384	—	0.985	O42384 →
Q8UUY8	—	0.983	Q8UUY8 →
O17899	—	0.983	O17899 →
A0A678XMK4	—	0.983	A0A678XMK4 →
P51052	—	0.983	P51052 →
Q8JG69	—	0.982	Q8JG69 →
HTR5A	5-hydroxytryptamine receptor 5A	0.982	landscape →
Q8CIM5	—	0.982	Q8CIM5 →