Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.77 |
| ▸ | TP53 | P04637 | 3/20 | 0.77 |
| ▸ | GAA | P10253 | 4/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.74 |
| ▸ | POLB | P06746 | 4/20 | 0.72 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.67 |
| ▸ | RAB9A | P51151 | 5/20 | 0.67 |
| ▸ | NPC1 | O15118 | 4/20 | 0.67 |
| ▸ | HPGD | P15428 | 3/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.67 |
| ▸ | USP2 | O75604 | 2/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.66 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.66 |
| ▸ | PPARG | P37231 | 1/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.66 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.66 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.66 |
| ▸ | MITF | O75030 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2624544 | 0.95 | SMN1; SMN2 (0.77) | MAPTTP53GAASMN1; SMN2POLB | |
| SCHEMBL10279091 | 0.90 | MAPT (0.75) | MAPTTP53GAASMN1; SMN2POLB | |
| SCHEMBL5997449 | 0.87 | MAPT (0.74) | MAPTTP53GAASMN1; SMN2POLB | |
| SCHEMBL12988671 | 0.87 | MAPT (0.71) | MAPTTP53GAASMN1; SMN2POLB | |
| SCHEMBL2624535 | 0.87 | MAPT (0.74) | MAPTTP53GAASMN1; SMN2POLB | |
| SCHEMBL2624542 | 0.87 | MAPT (1.00) | MAPTTP53GAASMN1; SMN2POLB | |
| SCHEMBL2740438 | 0.87 | MAPT (0.71) | MAPTTP53GAASMN1; SMN2POLB | |
| SCHEMBL2739989 | 0.85 | SMN1; SMN2 (1.00) | MAPTTP53GAASMN1; SMN2POLB | |
| SCHEMBL13977666 | 0.84 | MAPT (0.75) | MAPTTP53GAASMN1; SMN2POLB | |
| SCHEMBL2624537 | 0.84 | MAPT (0.67) | MAPTTP53GAASMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120100609-A1 | N-LINKED GLYCAN BIOSYNTHESIS MODULATORS | BIOMARIN PHARMACEUTICAL INC. | 2012-04-26 | — | — | US | disclosed |
| US-20100190807-A1 | CDKI Pathway inhibitors and uses thereof to regulate expression to TAU protein | SENEX BIOTECHNOLOGY, INC. | 2010-07-29 | — | — | US | disclosed |
| US-20090281129-A1 | CDKI PATHWAY INHIBITORS AND USES THEREOF | SENEX BIOTECHNOLOGY, INC. | 2009-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120100609-A1 | N-LINKED GLYCAN BIOSYNTHESIS MODULATORS | ENGASE, GALNT1, GALNT13 | MAPT 2982/4885TP53 4190/4885GAA 98/4885 |
| US-20100190807-A1 | CDKI Pathway inhibitors and uses thereof to regulate expression to TAU protein | MAPT, CDK5, CDKN1A | MAPT 1/4885TP53 343/4885GAA 2138/4885 |
| US-20090281129-A1 | CDKI PATHWAY INHIBITORS AND USES THEREOF | CDKN1A, CDK6, CCNI | MAPT 1424/4885TP53 182/4885GAA 1316/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.