Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.74 |
| ▸ | TP53 | P04637 | 3/20 | 0.74 |
| ▸ | POLB | P06746 | 4/20 | 0.70 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.70 |
| ▸ | RAB9A | P51151 | 6/20 | 0.63 |
| ▸ | NPC1 | O15118 | 4/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | GAA | P10253 | 3/20 | 0.62 |
| ▸ | HPGD | P15428 | 3/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.62 |
| ▸ | USP2 | O75604 | 1/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
| ▸ | PPARG | P37231 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.61 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.61 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10144065 | 0.87 | MAPT (0.77) | MAPTTP53POLBRXFP1RAB9A | |
| SCHEMBL2624544 | 0.87 | SMN1; SMN2 (0.77) | MAPTTP53POLBRXFP1RAB9A | |
| SCHEMBL10279091 | 0.86 | MAPT (0.75) | MAPTTP53POLBRXFP1RAB9A | |
| SCHEMBL2624535 | 0.85 | MAPT (0.74) | MAPTTP53POLBRXFP1RAB9A | |
| SCHEMBL2624542 | 0.85 | MAPT (1.00) | MAPTTP53POLBRXFP1RAB9A | |
| SCHEMBL2740438 | 0.83 | MAPT (0.71) | MAPTTP53POLBRXFP1RAB9A | |
| SCHEMBL12988671 | 0.83 | MAPT (0.71) | MAPTTP53POLBRXFP1RAB9A | |
| SCHEMBL23657588 | 0.81 | MAPT (0.84) | MAPTTP53POLBRXFP1RAB9A | |
| SCHEMBL2624540 | 0.81 | SIRT1 (0.82) | MAPTTP53POLBRXFP1RAB9A | |
| SCHEMBL2624537 | 0.81 | MAPT (0.67) | MAPTTP53POLBRXFP1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012065139-A2 | ENTPD5 INHIBITORS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2012-05-18 | — | — | WO | disclosed |