SCHEMBL10144158

Cc1cc(=O)n(C(=O)C2CC2)c2cc(NC(=O)[C@H](CCCCNC(=O)OC(C)(C)C)NC(=O)[C@H](COCc3ccccc3)NC(=O)OCC3c4ccccc4-c4ccccc43)ccc12

nearest known ligand 0.48

Predicted protein targets (top 15)

	gene	UniProt	supporting neighbours	confidence
▸	MDM2	Q00987	1/20	0.41

▸	TLR2	O60603	1/20	0.38

▸	TLR1	Q15399	1/20	0.38

▸	SIRT2	Q8IXJ6	6/20	0.38

▸	SIRT1	Q96EB6	6/20	0.38

▸	ITGB3	P05106	1/20	0.37

▸	ITGA2B	P08514	1/20	0.37

▸	SIRT5	Q9NXA8	2/20	0.37

▸	MEN1	O00255	1/20	0.37

▸	KMT2A	Q03164	1/20	0.37

▸	L3MBTL1	Q9Y468	1/20	0.37

▸	KLK7	P49862	1/20	0.37

▸	KLK5	Q9Y337	1/20	0.37

▸	CA1	P00915	1/20	0.36

▸	CA2	P00918	1/20	0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL10144109	0.90	MDM2 (0.42)	MDM2TLR2TLR1SIRT2SIRT1
SCHEMBL10144157	0.89	MDM2 (0.40)	MDM2TLR2TLR1SIRT2ITGB3
SCHEMBL10143586	0.88	MDM2 (0.42)	MDM2SIRT2SIRT1MEN1KMT2A
SCHEMBL10143415	0.88	CTSS (0.42)	MDM2TLR2TLR1SIRT2SIRT1
SCHEMBL10143408	0.88	MDM2 (0.41)	MDM2TLR2TLR1SIRT2SIRT1
SCHEMBL10143498	0.86	MDM2 (0.41)	MDM2SIRT2SIRT1SIRT5MEN1
SCHEMBL10144450	0.81	TLR2 (0.43)	MDM2TLR2ITGB3ITGA2B
SCHEMBL10144110	0.81	MDM2 (0.39)	MDM2SIRT2SIRT1SIRT5MEN1
SCHEMBL10144449	0.80	TLR2 (0.44)	MDM2TLR2ITGB3ITGA2B
SCHEMBL10143527	0.80	SIRT2 (0.42)	MDM2TLR2TLR1SIRT2SIRT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2012009258-A2	PEPTIDOMIMETIC GALANIN RECEPTOR MODULATORS	ROBERTS EDWARD (US)	2012-01-19	—	—	WO	disclosed