Sugi Predict

Sugi Predict / Targets / CTSS

CTSS

Cathepsin S · P25774 · CTSS on Sugi Atlas →

288,205 patent compounds predicted against CTSS, 142,905 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL86153 SCHEMBL86153 0.56 13/20
SCHEMBL86185 SCHEMBL86185 0.56 13/20
SCHEMBL52449 SCHEMBL52449 0.52 13/20
SCHEMBL86713 SCHEMBL86713 0.51 13/20
SCHEMBL165350 SCHEMBL165350 0.47 13/20
SCHEMBL165351 SCHEMBL165351 0.47 13/20
SCHEMBL42634 SCHEMBL42634 0.62 11/20
SCHEMBL16146 SCHEMBL16146 0.60 11/20
SCHEMBL16869 SCHEMBL16869 0.60 11/20
SCHEMBL18765 SCHEMBL18765 0.59 11/20
SCHEMBL30865 SCHEMBL30865 0.59 11/20
SCHEMBL30866 SCHEMBL30866 0.59 11/20
SCHEMBL30867 SCHEMBL30867 0.59 11/20
SCHEMBL45753 SCHEMBL45753 0.59 11/20
SCHEMBL208853 SCHEMBL208853 0.70 10/20
SCHEMBL245079 SCHEMBL245079 0.65 10/20
SCHEMBL43571 SCHEMBL43571 0.63 10/20
SCHEMBL250775 SCHEMBL250775 0.53 10/20
SCHEMBL75850 SCHEMBL75850 0.51 10/20
SCHEMBL142589 SCHEMBL142589 0.46 10/20

Clinical trials — most relevant to CTSS by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Combination Therapy With Camostat Mesilate + Hydroxychloroquine for COVID-19 PHASE4WITHDRAWN
Ulinastatin in Severe Acute Pancreatitis PHASE4SUSPENDED
Efficacy Study of Local Steroid Injection and Wrist Splinting for Carpal Tunnel Syndrome PHASE4COMPLETED
Impact of Ascorbic Acid on Post-Cardiothoracic Surgery Inflammation PHASE4COMPLETED
Efficacy and Safety of Favipiravir and Ribavirin Formulation for Treatment of COVID-19 PHASE2/PHASE3UNKNOWN
The Study of Quadruple Therapy Quercetin, Zinc, Metformin, and EGCG as Adjuvant Therapy for Early, Metastatic Breast Cancer and Triple-negative Breast Cancer, a Novel Mechanism EARLY_PHASE1UNKNOWN
Respiratory Cathepsins, Proteases Inhibitors and Glycosaminoglycans (GAG) in Mucopolysaccharidosis nanCOMPLETED
Diagnostic Value of Serum Cathepsin S and Chromogranin A in DKD nanNOT_YET_RECRUITING
Multimodal Approach of Electrotherapy Versus Nerve Flossing Technique in Patient With Carpal Tunnel Syndrome nanUNKNOWN
Turkish Adaptation of the CTS-6 Evaluation Tool: A Validation and Reliability Study nanNOT_YET_RECRUITING
Hematological Markers in Idiopathic Carpal Tunnel Syndrome nanCOMPLETED
Chemokine Mechanisms in Chronic Pelvic Pain nanCOMPLETED
Serum Basal Tryptase Levels in Healthy Children nanCOMPLETED
Ultrasound Measures and Clinical Outcomes in Healthy Individuals, Mild and Moderate Carpal Tunnel Syndrome Patients nanCOMPLETED
Rab 32 Gene Polymorphisms as a Prognostic Factor in Leprosy Patients nanRECRUITING
Synovial Fluid Bank From Arthritic Patients nanRECRUITING
Predicting Pancreatic Necrosis Using mitDNA nanUNKNOWN
Intraneural Facilitation as a Treatment for Carpal Tunnel Syndrome nanCOMPLETED
Pseudoexfoliation and Carpal Tunnel Study nanCOMPLETED
Cardiovascular Structure and Function in the Mucopolysaccharidoses nanACTIVE_NOT_RECRUITING
Effect of Mepolizumab on Severe Eosinophilic Asthma nanUNKNOWN
Correlation Between Serum Markers of Unstable Plaque and Virtual Histology of Unstable Plaque Visualized by IVUS nanCOMPLETED
Effect of Exercise on Ultrasound SWV in CTS Patients nanCOMPLETED
Acute Pancreatitis Targets (APT) Study nanCOMPLETED
SRT in Comparison to ERT on Immune Aspects and Bone Involvement in Gaucher Disease nanUNKNOWN
Genetic Newborn Screening for Cystinosis and Spinal Muscular Atrophy nanCOMPLETED
Screening of Lysosomal Storage Disorders Diseases in Minority Groups nanUNKNOWN
Evaluation of the Lung Nodule Sensitivity of Stationary Chest Tomosynthesis in Patients With Known Lung Nodules nanCOMPLETED
Comparison of Clinical Efficacy of Submucosal Dexamethasone and Oral Trypsin-chymotrypsin for Reduction of Postoperative Sequelae After Lower Third Molar Surgery nanRECRUITING
The Role of Vitamin K2 in Preventing Glucocorticoid-Induced Bone Loss in Children With Nephrotic Syndrome nanRECRUITING

Related proteins — ESM-2 sequence neighbours (a CTSS binder may also engage these)

ProteinNameSimilarity
P25326 — 1.000 P25326 →
Q8HY81 — 0.999 Q8HY81 →
O70370 — 0.999 O70370 →
Q8HY82 — 0.999 Q8HY82 →
Q5E968 — 0.998 Q5E968 →
P55097 — 0.998 P55097 →
P06797 — 0.997 P06797 →
CTSV Cathepsin L2 0.997 landscape →
O35186 — 0.996 O35186 →
P25975 — 0.995 P25975 →
Q9GKL8 — 0.994 Q9GKL8 →
P61276 — 0.994 P61276 →
A0A1S4F2V5 — 0.994 A0A1S4F2V5 →
Q80UB0 — 0.994 Q80UB0 →
Q3ZKN1 — 0.994 Q3ZKN1 →
A0A072UTP9 — 0.994 A0A072UTP9 →
P25773 — 0.994 P25773 →
O45734 — 0.994 O45734 →
P61277 — 0.994 P61277 →
Q02765 — 0.994 Q02765 →
Q9GLE3 — 0.994 Q9GLE3 →
P07154 — 0.993 P07154 →
P43236 — 0.993 P43236 →
Q9FGR9 — 0.993 Q9FGR9 →
Q5E998 — 0.993 Q5E998 →
CTSK Cathepsin K 0.993 landscape →
P83205 — 0.993 P83205 →
Q24940 — 0.993 Q24940 →
Q9JI81 — 0.992 Q9JI81 →
Q9GL24 — 0.992 Q9GL24 →