Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 19/20 | 0.39 |
| ▸ | PLK2 | Q9NYY3 | 17/20 | 0.39 |
| ▸ | PLK3 | Q9H4B4 | 14/20 | 0.37 |
| ▸ | BRD4 | O60885 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7750944 | 0.73 | PLK1 (0.37) | PLK1PLK2PLK3BRD4 | |
| SCHEMBL14193656 | 0.71 | PLK1 (0.37) | PLK1PLK2PLK3BRD4 | |
| SCHEMBL18475419 | 0.70 | PLK1 (0.38) | PLK1PLK2PLK3BRD4 | |
| SCHEMBL18476409 | 0.70 | PLK1 (0.38) | PLK1PLK2PLK3BRD4 | |
| SCHEMBL16984420 | 0.68 | PLK1 (0.37) | PLK1PLK2PLK3BRD4 | |
| SCHEMBL761490 | 0.66 | PLK1 (0.61) | PLK1PLK2PLK3BRD4 | |
| SCHEMBL30249002 | 0.66 | PLK1 (0.42) | PLK1PLK2PLK3BRD4 | |
| SCHEMBL30248840 | 0.66 | PLK1 (0.42) | PLK1PLK2PLK3BRD4 | |
| SCHEMBL10093296 | 0.66 | PLK1 (0.30) | PLK1PLK2PLK3 | |
| SCHEMBL27757435 | 0.64 | PLK1 (0.54) | PLK1PLK2PLK3BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2481739-A1 | DIHYDROPTERIDINONE DERIVATIVES, PREPARATION PROCESS AND PHARMACEUTICAL USE THEREOF | Jiangsu Hengrui Medicine Co., Ltd. (CN) | 2012-08-01 | — | — | EP | disclosed |
| EP-2079743-B1 | PTERIDINE DERIVATIVES AS POLO-LIKE KINASE INHIBITORS USEFUL IN THE TREATMENT OF CANCER | CHROMA THERAPEUTICS LTD (GB) | 2012-01-25 | — | — | EP | disclosed |
| WO-2008050096-A1 | PTERIDINE DERIVATIVES AS POLO-LIKE KINASE INHIBITORS USEFUL IN THE TREATMENT OF CANCER | CHROMA THERAPEUTICS LTD. (GB) | 2008-05-02 | — | — | WO | disclosed |