Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 15/20 | 0.44 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 2/20 | 0.39 |
| ▸ | TTK | P33981 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10146178 | 0.88 | LRRK2 (0.47) | LRRK2CXCR4CNR2SYK | |
| SCHEMBL13142130 | 0.88 | CXCR4 (0.40) | CXCR4SYK | |
| SCHEMBL10145297 | 0.86 | CNR2 (0.49) | LRRK2CXCR4CNR2 | |
| SCHEMBL15397172 | 0.84 | LRRK2 (0.44) | LRRK2CXCR4CNR2NR1H2SYK | |
| SCHEMBL12796227 | 0.84 | LRRK2 (0.48) | LRRK2CXCR4CNR2NR1H2 | |
| SCHEMBL541575 | 0.83 | LRRK2 (0.43) | LRRK2CXCR4CNR2NR1H2SYK | |
| SCHEMBL541576 | 0.83 | LRRK2 (0.43) | LRRK2CXCR4CNR2NR1H2SYK | |
| SCHEMBL541384 | 0.82 | LRRK2 (0.45) | LRRK2CXCR4CNR2NR1H2 | |
| SCHEMBL541383 | 0.82 | LRRK2 (0.45) | LRRK2CXCR4CNR2NR1H2 | |
| SCHEMBL13141747 | 0.81 | CNR2 (0.61) | CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2415765-A1 | PYRIMIDINE COMPOUND | Astellas Pharma Inc. (JP) | 2012-02-08 | — | — | EP | disclosed |