Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 12/20 | 0.72 |
| ▸ | PARG | Q86W56 | 3/20 | 0.43 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | S100B | P04271 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10146361 | 0.86 | GRM2 (0.62) | GRM2PARG | |
| SCHEMBL10145910 | 0.85 | GRM2 (0.60) | GRM2PARG | |
| SCHEMBL25865664 | 0.85 | GRM2 (0.80) | GRM2PARGPOLB | |
| SCHEMBL10145864 | 0.84 | GRM2 (0.59) | GRM2PARG | |
| SCHEMBL625809 | 0.84 | GRM2 (0.67) | GRM2PARGP2RX3POLB | |
| SCHEMBL10146645 | 0.83 | GRM2 (0.49) | GRM2PARG | |
| SCHEMBL10146668 | 0.82 | GRM2 (0.70) | GRM2PARG | |
| SCHEMBL10146655 | 0.82 | GRM2 (0.48) | GRM2PARGP2RX3 | |
| SCHEMBL10146647 | 0.82 | GRM2 (0.48) | GRM2PARGPOLB | |
| SCHEMBL10146651 | 0.82 | GRM2 (0.50) | GRM2PARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012021382-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | MERCK SHARP & DOHME CORP. (US) | 2012-02-16 | — | — | WO | disclosed |