Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 2/20 | 0.43 |
| ▸ | PARG | Q86W56 | 4/20 | 0.38 |
| ▸ | XDH | P47989 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14992645 | 0.92 | GRM2 (0.44) | GRM2PARGXDHKDM1ARAF1 | |
| SCHEMBL627802 | 0.90 | GRM2 (0.46) | GRM2PARGXDHKDM1ARAF1 | |
| SCHEMBL627819 | 0.88 | GRM2 (0.44) | GRM2PARGXDHPIK3CAGRIN1 | |
| SCHEMBL626150 | 0.85 | PIK3CA (0.41) | GRM2XDHPIK3CA | |
| SCHEMBL10145839 | 0.82 | PIK3CA (0.44) | GRM2PARGPIK3CAGRIN1GRIN2B | |
| SCHEMBL10146006 | 0.80 | PARG (0.40) | GRM2PARGPIK3CAGRIN1GRIN2B | |
| SCHEMBL14992707 | 0.78 | PARG (0.47) | GRM2PARG | |
| SCHEMBL627523 | 0.77 | PARG (0.45) | GRM2PARGXDHKDM1A | |
| SCHEMBL14992922 | 0.76 | GRM2 (0.40) | GRM2PARGXDH | |
| SCHEMBL627295 | 0.76 | GRM2 (0.43) | GRM2PARGGRIN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012021382-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | MERCK SHARP & DOHME CORP. (US) | 2012-02-16 | — | — | WO | disclosed |