Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 5/20 | 0.44 |
| ▸ | PRKDC | P78527 | 3/20 | 0.44 |
| ▸ | MTOR | P42345 | 2/20 | 0.37 |
| ▸ | PARG | Q86W56 | 5/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.33 |
| ▸ | AXL | P30530 | 2/20 | 0.33 |
| ▸ | MERTK | Q12866 | 2/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10145836 | 0.82 | GRM2 (0.39) | GRM2AXL | |
| SCHEMBL10146007 | 0.82 | GRM2 (0.43) | PIK3CAPARGGRM2GRIN1GRIN2B | |
| SCHEMBL10145837 | 0.82 | PARG (0.42) | PARGGRM2AXL | |
| SCHEMBL10146391 | 0.82 | TRIM24 (0.40) | PARGGRM2GRIN1GRIN2BAXL | |
| SCHEMBL10146006 | 0.82 | PARG (0.40) | PIK3CAPRKDCPARGGRM2GRIN1 | |
| SCHEMBL626150 | 0.81 | PIK3CA (0.41) | PIK3CAPRKDCMTORGRM2 | |
| SCHEMBL10146625 | 0.79 | GRM2 (0.36) | GRM2AXL | |
| SCHEMBL10146620 | 0.75 | POLB (0.35) | PARGGRIN1GRIN2BAXL | |
| SCHEMBL627819 | 0.75 | GRM2 (0.44) | PIK3CAPARGGRM2GRIN1GRIN2B | |
| SCHEMBL14992645 | 0.73 | GRM2 (0.44) | PARGGRM2GRIN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012021382-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | MERCK SHARP & DOHME CORP. (US) | 2012-02-16 | — | — | WO | disclosed |